妊娠相关焦虑与小于胎龄儿的关联研究  

Pregnancy-related anxiety associated with small-for-gestational-age infants

作　　者：来亚平[1] 严双琴 黄锟[1] 陈茂林 郝加虎[1] 毛雷婧 尤优[1] 陶芳标[1] Lai Yaping;Yah Shuangqin;Huang Kun;Chen Maolin;Hao Jiahu;Mao Leijing;You You;Tao Fangbiao(Department of Maternal,Child and Adolescent Health,School of Public Health,Anhui Medical University,Hefei 230032,Chin;Department of Ma＇anshan Maternal and Child Health Center,Ma＇anshan 243000,China)

机构地区：[1]安徽医科大学公共卫生学院儿少卫生与妇幼保健学系,合肥230032 [2]安徽省马鞍山市妇幼保健院,243000

出　　处：《中华流行病学杂志》2018年第10期1329-1332,共4页Chinese Journal of Epidemiology

基　　金：国家自然科学基金（81573168）

摘　　要：目的探讨孕中、晚期妊娠相关焦虑与小于胎龄儿的关联。方法基于马鞍山优生优育队列（于2013年5月至2014年9月建立），本研究将3 040对母婴纳入分析。通过妊娠相关焦虑量表了解孕中期和孕晚期妊娠相关焦虑。以出生体重低于同胎龄P10及高于同胎龄P90为界值，将新生儿划分为小于胎龄儿、适于胎龄儿和大于胎龄儿。通过χ2检验比较孕期不同特征在新生儿小于胎龄儿、大于胎龄儿及适于胎龄儿等组别中的分布差异，采用多项式logistic回归模型分析单因素及控制相关的混杂因素后孕中、晚期妊娠相关焦虑对小于胎龄儿的影响。结果小于胎龄儿和大于胎龄儿的发生率分别为9.6%、16.6%。仅孕中期或仅孕晚期存在妊娠相关焦虑与小于胎龄儿之间的关联无统计学意义；孕中、晚期均存在妊娠相关焦虑可增加小于胎龄儿的发生风险（OR=1.39，95%CI：1.04-1.87），与大于胎龄儿之间关联无统计学意义（OR=1.05，95%CI：0.81-1.35）。结论孕中、晚期均存在妊娠相关焦虑是小于胎龄儿发生的危险因素。Objective To investigate the second or third trimester pregnancy-related anxiety on small-for-gestational-age infants.Methods This study was based on Ma’anshan Birth Cohort Study （MABC）, with 3 040 maternal-singleton pairs finally selected for data analysis, from May 2013 to September 2014. The psychological state of pregnancy was evaluated according to a self-developed ＇anxiety scale for gestation’. Small-for-gestational-age was defined as ＇having birth weight below the 10th percentile at a particular gestational week’, while large-for-gestational-age infants was defined as ＇having birth weight above the 90th percentile’. Birth weight between the 10th and 90th percentile was classified as appropriate-for-gestational age infants. χ2 test was used to compare the distribution of characteristics in pregnancy among three groups with different birth weights. Multivariate logistic regression models were conducted to evaluate the associations between third trimester pregnancy- related anxiety and birth weight. Results The incidence rates of small- and large-gestational-age infants were 9.6% and 16.6%, respectively. Difference between women with only one of the second or third trimester pregnancy-related anxiety syndromes and small-for-gestational-age infants showed no statistical significance. Women with both second and third trimester pregnancy-related anxieties might increase the risk of small-for-gestational-age infants （OR=1.39, 95%CI： 1.04-1.87）. However, there was no significant difference between pregnancy-related anxiety and large-for- gestational-age infants （OR=1.05, 95%CI： 0.81-1.35） noticed.Conclusion Women with second and third trimester pregnancy-related anxiety appeared a risk factor for small-for-gestational-age infants.

关 键 词：妊娠相关焦虑 小于胎龄儿 

分 类 号：R714.2[医药卫生—妇产科学]