红花三七水煎剂对小鼠在体小肠平滑肌的作用  

The Effect of Sanqi Decoction on the Smooth Muscle of Small Intestine in Mice

作　　者：高猎防 何雄文[2] 牛美兰[1] 马俊远 李静[1] 胡晓凤[1] 郑梦晓 Gao Liefang;He Xiongwen;Niu Meilan;Ma Junyuan;Li Jing;Hu Xiaofeng;Zheng Mengxiao(.School of medicine, Huanghe Science and Technology College, Zhengzhou 450063; . Surgery, Henan Province Chinese Medicine Research Institute Affiliated Hospital, Zhengzhou 450004, China)

机构地区：[1]黄河科技学院医学院,河南郑州450063 [2]河南省中医药研究院附属医院外科,河南郑州450004

出　　处：《广东化工》2018年第19期42-43,共2页Guangdong Chemical Industry

基　　金：河南省教育厅重点课题;项目号:15A310021;河南省科技攻关重点项目;项目号:152102310170

摘　　要：目的:探讨红花、三七水煎剂对在体小鼠小肠平滑肌的推动作用。方法:取健康小鼠50只,随机分为新斯的明组、硫酸阿托品组、红花水煎剂组、三七水煎剂组、红花联合三七水煎剂组,每组各10只;新斯的明组小鼠灌胃0.002%新斯的明,硫酸阿托品组小鼠灌胃0.05%硫酸阿托品,红花水煎剂组小鼠灌胃6%红花水煎剂,三七水煎组小鼠灌胃6%三七水煎剂,红花联合三七水煎剂组小鼠灌胃6%红花联合三七水煎剂,灌药10分钟后对各组小鼠灌胃2%亚甲蓝,观察各组小鼠小肠推进率。结果:与硫酸阿托品组对比,其他组的小肠推进率显著增加(p<0.01);与新斯的明组对比,红花联合三七水煎剂组小肠推进率增加(p<0.05),红花水煎剂组、三七水煎剂组无明显差异(p>0.05);与红花联合三七水煎剂组相比,三七水煎剂组和红花煎剂组小肠推进率显著降低(p<0.01);红花水煎剂组与三七水煎剂组相比,小鼠小肠推进率无明显差异(p>0.05)。结论:红花、三七水煎剂具有促进小鼠小肠推进的作用;红花联合三七水煎剂对小鼠小肠的推动效果明显好于新斯的明。Objective： To observe the effect of saffron on the peristalsis of small intestinal smooth muscle in mice. Methods： 50 healthy mice were randomly divided into the group of neostigmine, the group of atropine sulfate, the group of safflower decoction, the group of sanqi decoction, the combination group of safflower decoction and sanqi decoction, each group of 10 mice. The group of neostigmine were given 0.002 % of neostigmine by gavage. The group of atropine sulfate were given 0.05 % of atropine sulfate by gavage. The group of safflower decoction were given 6 % of safflower decoction by gavage. The group of sanqi decoction were given 6 % of sanqi decoction by gavage. The combination group of safflower decoction and sanqi decoction were given 6 % of afflower decoction and sanqi decoction by gavage. All groups were given 2 % of methylene blue by gavage after ten minutes. Results： Compared with the group of atropine sulfate, the propulsion rate of methylene blue increased significantly in other groups（p 0.01）, there was no significant difference in propulsive rate between in propulsive rate the group of safflower decoction and sanqi decoction（p0.05）. Compared with the combination group of safflower decoction and sanqi decoction, the propulsion rates of methylene blue decreased significantly（p0.01）. There was no significant difference in propulsive rate between safflower decoction and sanqi decoction（p0.05）. Conclusion： Safflower decoction and sanqi decoction have the effect of promoting intestinal peristalsis in mice. The combination group of safflower decoction and sanqi decoction have a better effect on promoting intestinal peristalsis in mice than neostigmine.

关 键 词：红花 三七 在体小肠平滑肌 小鼠 

分 类 号：R96[医药卫生—药理学]