仿生微流控肝芯片研究进展  

Advances in the Study of Liver-on-Chips with Bionic Microfluidic

作　　者：厉海笛 陈晓萍 Li Haidi;Chen Xiaoping(College of Biotechnology and Bioengineering,Zhejiang University of Technology,Hangzhou 310000,China)

机构地区：[1]浙江工业大学生物工程学院,杭州310000

出　　处：《中国生物医学工程学报》2018年第5期625-630,共6页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金(81241097)

摘　　要：仿生微流控器官芯片是生物医药研究领域的一个前沿热点,它在微型芯片上建立起模拟人体器官的微组织,并带有高通量检测功能,在药物研发与毒性评价中具有重要的应用前景。肝脏是人体的代谢中枢,易于受到化合物毒害,其肝毒性是药物毒性评价中的重要指标。近年来,有关仿生微流控肝芯片的研究有大量的研究成果。概括和总结这种芯片的基本设计理念、微通道灌流方式、细胞体系,并讨论其主要应用前景和未来的发展趋势。One of the recent frontier hotspots in biomedical field is organ-on-chips with bionic microfluidic. The chips comprise of micro-tissues that mimic in vivo organs and are able to realize high-throughput detection, which have potential wide applications in the drug discovery and toxicity testing. The liver, a metabolic center of human body, is sensitive for chemicals poison and essential to evaluate the hepatotoxicity in toxicity testing. In recent years the advance in this field come out a great deal of results in liver-on-chips with bionic microfluidic. In this review, we provided an overview of the design concepts, micro-channel perfusion methods and cell culture systems. We also discussed the application prospects and the future trends of liver-on-chips.

关 键 词：仿生微流控 器官芯片 肝毒性 

分 类 号：R318[医药卫生—生物医学工程]