银杏叶注射液对老年高血压冠心病患者内皮素及冠脉血流的影响  

Effect of Ginkgo Biloba Injection on Plasma Levels of Endothelin and Coronary Blood Flow in Elderly Hypertensive Patients with Coronary Heart Disease

作　　者：岑运光[1] 李伟[1] 张旭日[1] 吴多智[1] CEN Yunguang;LI Wei;ZHANG Xuri;WU Duozhi(Medical and Health Center,Hainan Provincial People,s Hospital,Haikou 570311,Hainan,China)

机构地区：[1]海南省人民医院医疗保健中心

出　　处：《中华中医药学刊》2018年第11期2754-2756,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：海南省医药卫生科研项目(14A200038)

摘　　要：目的：观察银杏叶注射液对老年高血压冠心病患者内皮素及冠脉血流的影响。方法：老年高血压冠心病患者138例,随机分为两组,采用常规治疗,对照组服用辛伐他汀分散片;观察组加用银杏叶注射液治疗。观察两组患者临床疗效,检测治疗前后两组内皮素水平情况,采用TIMI危险评分及PCI术行冠脉造影检查评价冠脉血流情况,并观察患者术后心电图ST段回落情况。结果：观察组临床总有效率95.65%,对照组总有效率85.51%,观察组临床疗效明显优于对照组（P〈0.05）。两组患者经治疗后ET-1观察组明显较低,NO观察组明显较高,差异有统计学意义（P〈0.05）。经治疗观察组心电图ST及冠脉血流改善情况明显优于对照组,TIMI危险评分明显低于对照组（P〈0.05）。结论：银杏叶注射液能显著增加老年冠心病患者冠状动脉左前降支血流,提高冠心病患者NO水平,降低ET水平,具有良好的应用前景。Objective：The effect of Ginkgo biloba injection on endothelin and coronary blood flow in elderly patients with coronary heart disease was observed. Methods：138 Senile coronary heart disease patients were randomly divided into two groups, the control group taking Simvastatin Dispersible Tablets; the observation group treated with Ginkgo biloba injection. To observe the clinical efficacy of the two groups before and after treatment in two groups, detection of endothelin, observe the clinical effect of two groups were detected before and after treatment, two groups of endothelin levels, using TIMI risk score and PCI patients underwent coronary angiography to evaluate coronary blood flow, and postoperative ECG ST segment resolution.Result：he total effective rate of the observation group was 95.65%, the total effective rate of the control group was 85.51%, and the clinical effect of the observation group was obviously better than that of the control group（P〈0.05）. After the treatment of the two groups, the ET-1 observation group was significantly lower, and the NO observation group was significantly higher, and the difference was statistically significant（P〈0.05）. The CFR in the observation group was also significantly higher than that in the control group, and the difference was statistically significant（P〈0.05）. The improvement of ST and coronary blood flow in the treatment group was better than that of the control group, and the risk score of TIMI was significantly lower than that of the control group（P〈0.05）.Conclusion：Ginkgo biloba injection can significantly increase the blood flow of the left anterior descending coronary artery in elderly patients with coronary heart disease, improve the level of NO in patients with coronary heart disease, and reduce the level of ET, which has a good application prospect.

关 键 词：银杏叶注射液 冠心病 内皮素 冠脉血流 

分 类 号：R541.4[医药卫生—心血管疾病]