维持性腹膜透析患者不宁腿综合征患病率及危险因素分析  

Prevalence and risk factors of restless legs syndrome in maintenance peritoneal dialysis patients

作　　者：于晓丽[1] 林建雄[1] 易春燕[1] 毛海萍[1] 余学清[1] 阳晓[1] Yu Xiaoli; Lin Jianxiong; Yi Chunyan; Mao Haiping; Yu Xueqing; Yang Xiao(Department of Nephrology, the First Affiliated Hospital, Sun Yat- sen University and Key Laboratory of Nephrology, National Health Commission and Guangdong Province, Guangzhou 510080, China)

机构地区：[1]中山大学附属第一医院肾内科 卫健委和广东省重点实验室,广州510080

出　　处：《中华肾脏病杂志》2018年第10期721-726,共6页Chinese Journal of Nephrology

基　　金：国家重点研发计划项目（2016YFC0906101）;国家自然科学基金（81774069、81570614）;卫健委公益性行业科研专项（201502023）;广东省肾脏病重点实验室运行经费（20148030301023）

摘　　要：目的探讨维持性腹膜透析（腹透）患者不宁腿综合征（RLS）的临床特点及相关危险因素。方法采用横断面研究的方法，纳入2015年7月至2016年6月在中山大学附属第一医院腹透中心的随访患者为研究对象。用国际不宁腿综合征研究小组标准问卷评估本中心腹透患者RLS患病率及严重程度。收集患者人口学资料、临床资料、实验室资料及合并症情况，分析RLS患者临床特点、患病率及严重程度。多因素Logistic回归法分析腹透患者发生RLS的危险因素。结果共纳入421例腹透患者，年龄（46．3±12．8）岁，女性占比为44．2％，合并糖尿病占比为17．3％，中位透析龄为46．8（28．0，73．5）个月。腹透患者RLS患病率为14．0％，以中、重度为主。多因素Logistic回归分析结果显示，低龄、长透析龄、高血钙、高血磷是腹透患者发生RLS的独立危险因素（均Pc0．05）。结论本中心腹透患者RLS患病率为14．0％，以中、重度为主。低龄、长透析龄、高血钙、高血磷是腹透患者发生RLS的独立危险因素。Objectives To investigate the prevalence and its risk factors of restless legs syndrome （RLS） in maintenance peritoneal dialysis （PD） patients. Methods Patients who performed PD in the First Affiliated Hospital of Sun Yat-sen University were recruited by convenience sampling. International Restless Legs Syndrome Study Group diagnostic criteria and International Restless Leg Syndrome rating scale were used to diagnose and evaluate the RLS and its severity. Co-morbidities level, baseline demographic, clinical and biochemical data were collected to analyze the clinical characteristics of patients with RLS. Multivariate logistic regression analysis was used to assess the risk factors for RLS. Results A total of 421 PD patients were enrolled in this study. Their age was （46.3＋ 12.8） years old, 44.2% were female and 17.3% with diabetes. The median vintage of PD was 46.8（28.0, 73.5） months. The prevalence of RLS was 14.0%, most of whom were affected with moderate or severe RLS. Logistic regression analysis showed that younger age, long-term dialysis duration, higher serum calcium and phosphorus were the risk factors associated with RLS in PD patients after adjustment for confounders （all P 〈 0.05）. Conclusions Prevalence of RLS in PD patients is 14.0%. Younger age,long-term dialysis duration, higher serum calcium and phosphorus were the risk factors associated with RLS.

关 键 词：腹膜透析 不宁腿综合征 危险因素 

分 类 号：R692.5[医药卫生—泌尿科学]