血小板源性生长因子-D(PDGF-D)基因研究进展  

Research Advances in Platelet-derived Growth Factor-D(PDGF-D) Gene

作　　者：卢曾奎 杜立新[1] 张利平[2] 李青 储明星[1] 魏彩虹[1] LU Zeng-Kui;DU Li-Xin;ZHANG Li-Ping;LI Qing;CHU Ming-Xing;WEI Cai-Hong(Institute of Animal Science,Chinese Academy of Agricultural Sciences,Beijing 100193,China;College of Animal Science and Technology,Gansu Agricultural University,Lanzhou 730070,China)

机构地区：[1]中国农业科学院北京畜牧兽医研究所,北京100193 [2]甘肃农业大学动物科学技术学院,兰州730070

出　　处：《农业生物技术学报》2018年第11期1970-1978,共9页Journal of Agricultural Biotechnology

基　　金：国家肉羊产业技术体系项目(CARS-38);国家自然科学基金项目(No.31672380)

摘　　要：血小板源性生长因子-D (platelet-derived growth factor-D, PDGF-D)是PDGF家族新成员,可以调节血管生成、组织纤维化、肿瘤发生发展和脂肪代谢等多个生物学过程,且与绵羊(Ovis aries)尾部脂肪沉积和尾型密切相关,可以作为尾型选育的候选基因。PDGF-D和PDGFR-β(血小板源性生长因子受体β,platelet-derived growth factor receptorβ)特异性结合后才能激活一系列信号通路来调节细胞增殖、分化和凋亡等细胞过程。本研究主要介绍了PDGF-D基因的发现与结构、表达、生理功能和信号传导通路的研究进展,并对未来PDGF-D基因的研究重点进行展望,为进一步研究PDGF-D基因提供一定的参考依据。Platelet-derived growth factor-D （PDGF-D） is a new member of PDGF family, it can regulate many biological processes, including angiogenesis, tissue fibrosis, tumorigenesis and lipid metabolism. It was found that PDGF-D is closely related to the sheep （Ovis aries） tail fat deposition and tail type, this gene could be used as candidate gene for tail type selection. PDGF-D can specifically bind to and activate its cognate receptor PDGFRβ （platelet-derived growth factor receptor β）, then regulate many cellular processes, including cell proliferation, differentiation and apoptosis. This review introduced the discovery, structure, expression, physiological function and signal transduction pathway of PDGF-D gene, proposed the research emphasis of PDGF-D gene in the future. This article provides a valuable reference for PDGF-D gene research.

关 键 词：PDGF-D基因 结构和表达 生理功能 信号通路 

分 类 号：S813[农业科学—畜牧学] Q953[农业科学—畜牧兽医]