宁泌泰胶囊治疗上尿路结石术后残余结石及并发症的临床疗效观察  

Curative effects of Ningmitai capsules on the residual fragments and postoperative complicationsfollowing lithotripsy treatment of upper urinary calculi

作　　者：向威[1] 郭永连 张景宇 郑涛[4] 章传华[1] Xiang Wei;Guo Yonglian;Zhang Jingyu;Zheng Tao;Zhang Chuanhua(Department of Urology,Wuhan Ist Hospital,Wuhan 430000,China)

机构地区：[1]武汉市第一医院泌尿外科,430000 [2]武汉市第二医院泌尿外科 [3]武汉市第三医院泌尿外科 [4]武汉市普爱医院泌尿外科

出　　处：《中华外科杂志》2018年第10期776-780,共5页Chinese Journal of Surgery

摘　　要：目的探讨清热利湿中成药宁泌泰胶囊在上尿路结石术后促进排石及并发症治疗方面的效果。方法采用随机平行对照研究。2016年10月至2018年3月于武汉市第一医院、武汉市第二医院、武汉市第三医院、武汉市普爱医院纳入上尿路结石外科治疗术后有残余结石的患者，按1：3的比例随机分为对照组和宁泌泰组。对照组按需给予抗菌药物或双氯芬酸钠栓剂治疗，宁泌泰组在对照组用药基础上加用宁泌泰胶囊（4粒次，3次／d，口服）。观察期限为自纳入至满12周止，期间观察残余结石的排出时间、排净时间、结石排净率，并比较两组术后并发症如疼痛、感染的情况。组间定量资料的比较采用成组设计的两样本比较的t检验，分类资料的比较采用χ2检验。结果共纳入符合标准的患者269例（武汉市第一医院86例，武汉市第二医院69例，武汉市第三医院58例，武汉市普爱医院56例），患者随机分为对照组66例，宁泌泰组203例。宁泌泰组结石排出时间[（4．5±0．4）d比（7．5±1．3）d，t=2．877，P=0．004]排净时间[（13．6±1．0）d比（25．6±3．8）d，t=4．252，P=0．000]均短于对照组。治疗4周后，宁泌泰组结石排净率高于对照组（91．6％比68．2％，χ2=2．57，P：0．000）。治疗12周后，对照组患者总有效率为89．4％，宁泌泰组总有效率为99．5％，差异有统计学意义（χ2=17．65。P=0．000）。宁泌泰组镇痛患者比例低于对照组（16．3％比30．3％，χ2=6．212，P=0．013），术后4周的尿常规白细胞转阴率高于对照组（88．2％比71．2％，χ2=10．67，P：O．001）。两组患者均未见明显不良反应。结论宁泌泰胶囊可促进术后残余结石的排出，提高残余结石排净率．有助于结石术后疼痛、感染等并发症的预防和治疗。Objective To observe the clinical efficacy of Ningmitai capsules, a traditional Chinese medicine using for clearing heat and dampness, in the treatment of residual fragments and postoperative complications following litbotripsy for upper urinary stones. Methods During October 2016 and March 2018, patients from Wuhan 2nd Hospital, Wuhan 2nd Hospital, Wuhan and Hospital, and Wuhan Puai Hospital having upper urinary residual fragments following minimally-invasive stone treatment were randomly assigned to control group and Ningmitai group with a proportion of 1 ： 3. The patients in control group were treated with antibiotics or sodium diclofenac suppository on demand, while patients in Ningmitai group took additional Ningmitai capsule orally （4 capsules per time, 3 times per day）. The observation was started when a patient was enrolled in this study and continued for a maximum of 12 weeks or until stone-free status. During the observation, the stone expulsion time, stone-free time, stone-free rate were observed, and the difference in curative effect between the two groups on postoperative complications such as pain and infection were compared. Statistical analysis was done using t-test or χ2 test by GraphPad Prism 5 software. Results Totally 269 cases enrolled in this study. Eighty-six patients were from Wuhan Ist Hospital, 69 patients from Wuhan 2nd Hospital, 58 patients from Wuhan 56 Hospital, 56 patients from Wuhan Puai Hospital, respectively. There were 66 cases in control group and 203 cases in Ningmitai group. The residual fragments expulsion time in Ningmitai group was significantly earlier than that in control group （ （4. 5 ＋0.4） days vs. （7.5＋ 1.3） days, t = 2. 877, P = 0. 004）, the residual fragments clearance time in Ningmitai group was significantly shorter than that in control group （ （13.6＋1.0） days vs. （25.6＋3.8） days, t =4. 252, P= 0. 000）, and the stone-free rate within 4 weeks post operation in Ningmitai group was significantly higher than control group （91.6

关 键 词：尿路结石症 中草药 手术后并发症 

分 类 号：R699[医药卫生—泌尿科学]