经导管栓塞兔胃左动脉体重下降的实验研究  

Weight loss after transcatheter left gastric arterial embolization in rabbit model

作　　者：付金鑫 刘凤永[1] 张金龙[2] 管阳[1] 阎洁羽[1] 王燕[1] 袁凯[1] 李鑫[1] 袁宏军 王茂强[1] Fu Jinxin;Liu Fengyong;Zhang Jinlong;Guan Yang;Yah Jieyu;Wang Yan;Yuan Kai;Li Xin;Yuan Hongjun;Wang Maoqiang(Department of Interventional Radiology,Chinede PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院介入放射科,北京100853 [2]南开大学医学院

出　　处：《中华放射学杂志》2018年第10期789-793,共5页Chinese Journal of Radiology

摘　　要：目的探讨新西兰白兔肥胖模型经导管胃左动脉栓塞术后体重、胃饥饿素水平变化情况，并评估其安全性。方法将新西兰白兔肥胖模型30只随机分成3组，每组10只。A组：经导管明胶海绵颗粒栓塞胃左动脉；B组：经导管明胶海绵颗粒栓塞胃左动脉及胃十二指肠动脉；C组（对照组）：经导管生理盐水灌注胃左动脉及胃十二指肠动脉。术前及术后1、2、3、4周分别测定胃饥饿素、空腹体重及肝肾功能。采用t检验比较各组术前及术后平均胃饥饿素、体重、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、肌酐及尿素水平的差异。采用重复测量的方差分析比较3组间术前及术后各时间点各值水平的差异。结果A组手术前、后胃饥饿素水平分别为（4 057±61）、（3 708±141）pg/ml，差异有统计学意义（t=4.5，P〈0.05）；B组手术前、后胃饥饿素水平分别为（4 137±89）、（3 608±239）pg/ml，差异有统计学意义（t=6.8，P〈0.05）；对照组手术前、后胃饥饿素水平分别为（3 986±82）、（4 044±72）pg/ml，差异无统计学意义（t=0.7，P〉0.05）。B组胃饥饿素水平下降程度较A组显著，差异有统计学意义（t=3.8，P〈0.05）。各组间术后胃饥饿素水平的差异有统计学意义（F=15.6；P〈0.05）。A组手术前、后体重分别为（6.12±0.38）、（5.66±0.39）kg，差异有统计学意义（t=2.7，P〈0.05）；B组手术前、后体重分别为（5.99±0.57）、（5.24±0.61）kg，差异有统计学意义（t=3.1，P〈0.05）；对照组手术前、后体重分别为（5.94±0.45）、（6.24±0.42）kg，差异无统计学意义（t=1.2，P〉0.05）。B组体重下降程度较A组显著，差异有统计学意义（t=5.2，P〈0.05）。各组间术后体重的差异有统计学意义（F=5.1，P〈0.05）。各组术前及术后各时间点ALT、AST、肌酐及尿素水平的差异均无统计学意义（P〉0.05）�ObjectiveTo investigate weight, ghrelin changes following transcatheter left gastric artery embolization in rabbit model of obesity, and evaluate its safety.MethodsThirty New Zealand rabbits were randomly divided into three groups, ten New Zealand rabbits in each group, group A： left gastric artery embolization using gelatin sponge, group B： left gastric artery and gastroduodenal artery embolization using gelatin sponge, group C （control group）： left gastric artery and gastroduodenal artery perfusion using normal saline. Ghrelin, weight and liver and kidney function were measured at preoperative and postoperative 1, 2, 3, 4 weeks. T test was used to compare the differences in the levels of preoperative and postoperative average ghrelin, weight, alanine transaminase （ALT）, aspartate transaminase （AST）, creatinine and urea in each group. The ANOVA of repeated measurement was used to compare the difference of preoperative and postoperative each time points between the three groups.ResultsThe preoperative and postoperative ghrelin levels in group A were （4 057±61）and （3 708±141） pg/ml with statistically significant differences （t=4.5, P〈0.05）. The preoperative and postoperative ghrelin levels in group B were （4 137±89） and （3 608±239） pg/ml with statistically significant differences （t=6.8, P〈0.05）. The preoperative and postoperative ghrelin levels in the control group were （3 986±82）and （4 044±72） pg/ml with no statistically significant differences （t=0.7, P〉0.05）. The level of ghrelin in group B decreased significantly compared with group A and the difference was statistically significant （t=3.8, P〈0.05）. There was a statistically significant difference in postoperative ghrelin levels between the three groups （F=15.6, P〈0.05）. The preoperative and postoperative weight in group A were （6.12±0.38）and （5.66±0.39） kg with statistically significant differences （t=2.7, P〈0.05）. The preoperative and postoperative weight in group

关 键 词：栓塞 治疗性 减肥手术 胃泌素类 

分 类 号：R589.2[医药卫生—内分泌]