尿N-乙酰-β-氨基葡萄糖苷酶在老年心血管疾病病人急性发作期的临床意义  

Clinical significance of urinary N-aeetyl-beta-D-glucosaminidase in the elderly patients with acute attack of cardiovascular disease

作　　者：崔瑶[1] 陈莹[1] 郭英[1] CUI Yao;CHEN Ying;GUO Ying(Department of Geriatrics,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院老年科,北京市100730

出　　处：《实用老年医学》2018年第10期939-942,共4页Practical Geriatrics

基　　金：首都全科医学研究专项课题(16QK15)

摘　　要：目的研究尿N-乙酰-β-氨基葡萄糖苷酶(NAG)在老年心血管疾病病人急性发作期的临床意义。方法选择2016年5月至2017年5月北京同仁医院老年科收治的年龄≥60岁的住院病人207例,分为急性期组94例和对照组113例,并将急性期组分为重度动脉硬化组23例和轻度动脉硬化组71例。记录一般情况,观察并比较糖化血红蛋白(HbA1c)、血清肌酐(SCr)、尿素氮(BUN)、尿酸(UA)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、NAG水平,计算并比较动脉粥样硬化指数(AI)及肾小球滤过率(eGFR)。结果急性期组除HbA1c外其他生化指标与对照组比较,差异均无统计学意义(P>0. 05),但NAG水平明显高于对照组,差异有统计学意义(P<0. 05)。重度动脉硬化组各生化指标与对照组比较,差异均无统计学意义(P<0. 05),但尿NAG值显著高于轻度动脉硬化组,差异有统计学意义(P<0. 01)。结论尿NAG不仅对老年心血管疾病病人急性发作期有很好的预测价值,而且可能作为一种炎症因子成为动脉粥样硬化进展的预测指标。Objective To study the clinical significance of urinary N-aeetyl-beta-Dglucosaminidase（ NAG） in the elderly patients with acute attack of cardiovascular disease（ CVD）.Methods A total of 207 elderly patients in the Department of Geriatrics of Beijing Tongren Hospital from May 2016 to May 2017 were enrolled and were divided into the acute group（ 94 cases） and the control group（ 113 cases）; Further,the acute group was divided into the severe arteriosclerosis group（ 23 cases）and the mild arteriosclerosis group（ 71 cases）. The clinical data of the patients were recorded. The levels of glycated hemoglobin A1c（ HbA1c）,high-sensitivity C-reactive protein（ hsCRP）,serum creatinine（ Scr）,blood urea nitrogen（ BUN）,uric acid（ UA）,total cholesterol（ TC）,triglyceride（ TG）,high density lipoprotein cholesterol（ HDL-C）,low density lipoprotein cholesterol（ LDL-C） and NAG were detected,and the atherosclerotic index and estimated glomerular filtration rate（ e GFR） were calculated and compared. Results There were no significant difference in biochemical indexes except HbA1c between the acute group and control group（ P〈0. 05）,but the urinary NAG level in the acute group was significantly higher than that in the control group（ P〈0. 05）. There were no significant difference in biochemical indexes between the severe arteriosclerosis group and mild arteriosclerosis group（ P〈0. 05）,but the urinary level of NAG in the severe arteriosclerosis group was significantly higher than that in the mild arteriosclerosis group（ P〈0. 01）. Conclusions Urinary NAG not only has a good predictive value in the elderly patients with acute attack of CVD,but also may become a predictor for progression of atherosclerosis.

关 键 词：尿N-乙酰-β-氨基葡萄糖苷酶 动脉粥样硬化 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]