乙醇和同型半胱氨酸代谢与心血管疾病关系的研究进展  

Research progress on relationship between metabolism of alcohol and homocysteine and cardiovascular diseases

作　　者：李栋[1] 张平安[1] LI Dong;ZHANG Ping-an(Department of Laboratory Science,Renmin Hospital of WuHan University,Wuhan Hubei,430060,China)

机构地区：[1]武汉大学人民医院检验科,湖北武汉430060

出　　处：《职业与健康》2018年第20期2860-2864,2868,共6页Occupation and Health

摘　　要：同型半胱氨酸(Homocysteine,Hcy)是含硫氨基酸,是必需氨基酸甲硫氨酸新陈代谢中的中间产物。血浆同型半胱氨酸水平受单核苷酸多态性(SNP)MTHFR C677T影响。除遗传因素外,环境因素也对同型半胱氨酸血浆浓度产生影响,比如慢性乙醇摄入与同型半胱氨酸血浆浓度升高有关。血浆同型半胱氨酸浓度的升高被认为是乙醇戒断发作的预测因素,并且由于同型半胱氨酸是一种心血管危险因素,可能导致乙醇依赖患者心肌梗塞的风险增加。本文对乙醇和同型半胱氨酸代谢与心血管疾病发病机制给予综述。Homocysteine（Hcy） is a sulfur-containing amino acid that is an intermediate in the metabolism of the essential amino acid methionine. Plasma Hcy levels are influenced by the single-nucleotide polymorphism（SNP） MTHFR C677 T. Besides genetic factors,environmental factors have an impact on plasma Hcy level. Thus,chronic alcohol intake is associated with elevated plasma Hcy concentration. Elevation of plasma Hcy concentration is considered as a predictor for the occurrence of alcohol withdrawal seizures,and as Hcy is a cardiovascular risk factor,it might contribute to the higher risk for myocardial infarction among alcohol dependent patients. The review summarizes the pathogenesis of alcohol and Hcy metabolism and cardiovascular disease.

关 键 词：乙醇 同型半胱氨酸 心血管疾病 代谢 

分 类 号：R181.3[医药卫生—流行病学]