二-(2-氯乙基)磷酸二酯的连续化生产工艺研究  

A Continuous Process for the Production of Bis(2-chloroethyl)(2-chloroethyl) phosphonate

作　　者：季盛 季国炎 杨华东 季小英 丁成荣[2] Jl Shen;Jl Guo-yan;YA NG Hua-dong;Jl Xiao-ying;DING Cheng-rong(Shaoxing Eastlake High-Tech Company Ltd.,Shaoxing 312074,China;College of Chemical Engineering,Zhejiang University of Technology,Hangzhou 310014,China)

机构地区：[1]绍兴东湖高科股份有限公司,浙江绍兴312074 [2]浙江工业大学化学工程学院,浙江杭州310014

出　　处：《精细化工中间体》2018年第4期19-21,共3页Fine Chemical Intermediates

基　　金：绍兴市重大科技攻关项目:高纯度乙烯利绿色连续化生产关键共性技术研究及产业化(2017A11001)

摘　　要：以三(2-氯乙基)亚磷酸酯为原料,利用1 mm环形管路的高效传热,及时转移重排过程中的反应热,使反应器内温度稳定,最终二-(2-氯乙基)磷酸二酯的含量由原间歇式反应釜生产的80%～85%提升到96%以上,成功制得了95%以上的乙烯利原药。Tris（2-chloroethyl） phosphite was transformed to bis（2-chloroethyl）（2-chloroethyl） phosphonate via rearrangement reaction. Using a 1 mm-annular pipe to timely transfer the heat of reaction during rearrangement process, the temperature inside the reactor was stable. The purity of bis（2-chloroethyl）（2-chloroethyl） phosphonate was increased from 80%-85% to more than 96%. This method provided the possibility for the successful preparation of more than 95% of the original drug ethephon.

关 键 词：重排反应 环形管路 乙烯利 

分 类 号：TQ231[化学工程—有机化工]