创新抗肿瘤药物A111P小鼠急性毒性研究  

Acute toxicology research of anti-tumor drugs A111P on mice

作　　者：张志妮 郭中敏[1] 黄玲[2] 严楚 ZHANG Zhi-ni; GUO Zhong-min; HUANG Ling; YAN Chu(Labboratory Animal Center, Sun Yat-sen University, Guangzhou , Guangdong 510006 ;School of Pharmaceutical, Sun Yat-sen University, Guangzhou, Guangdong 510006; Zhong Luotan Town Branch of Guangzhou Baiyun District Animal Health Supervision Institute, Guangzhou, Guangdong 510550, China)

机构地区：[1]中山大学实验动物中心,广东广州510006 [2]中山大学药学院,广东广州510006 [3]广州市白云区钟落潭镇畜牧兽医站,广东广州510550

出　　处：《热带医学杂志》2018年第10期1292-1294,1321,共4页Journal of Tropical Medicine

摘　　要：目的研究创新抗肿瘤药物A111P小鼠急性毒性情况,为新药研发提供依据。方法选用昆明小鼠为研究对象,采用上下法和半数致死量法考察创新抗肿瘤药物A111P的急性毒性情况。结果 A111P小鼠腹腔注射给药,上下法估算半数致死量(median lethal dose,LD_(50))为327.3 mg/kg,95%CI为175~550 mg/kg;半数致死量法表明LD_(50)为245.875 mg/kg,95%CI为201.854～308.474 mg/kg。结论创新抗肿瘤药物A111P安全性较好,安全范围较大,具有较好的应用前景。Objective To study the acute toxicology of anti-tumor drug A111 P on mice,and provide foundation for clinical research. Methods KM mice were selected in this study. High and low and median lethal dose were used to study the acute toxicity of anti-tumor drugs A111 P. Results The estimated LD50 of A111 P was 327.3 mg/kg,and the 95%CI was 17-550 mg/kg in high and low doasge. The LD50 of A111 P was 245.875 mg/kg,and the 95%CI was 201.854～308.474 mg/kg in classical median lethal dose. Conclusion Anti-tumor drugs A111 P had low actue toxicity and could be developmented as new drug.

关 键 词：A111P 急性毒性 小鼠 

分 类 号：R967[医药卫生—药理学]