颈动脉斑块稳定性与血清hs-CRP、MMP-9、TIMP-1表达水平的相关性研究  

The correlation between carotid plaque stability and the serum level of Hs-CRP,MMP-9 and TIMP-1

作　　者：丁尚伟[1] 谢玉环[1] 李润雄 罗根培 陈巧琼[1] 彭悦 郭焕如 Ding Shangwei;Xie Yuhuan;Li Runxiong;Luo Genpei;Chen Qiaoqiong;Peny Yue;Guo Huanru(Department of Ultrasound,Dongguan People＇s Hospital Affiliated to Southern Medical University,Dongguan 523059,China;Department of Neurology,Dongguan People＇s tlospital Affiliated to Southern Medical University,Dongguan 523059,China)

机构地区：[1]南方医科大学附属东莞人民医院超声科,广东省东莞523059 [2]南方医科大学附属东莞人民医院神经内科,广东省东莞523059

出　　处：《中国医师杂志》2018年第10期1506-1509,共4页Journal of Chinese Physician

基　　金：东莞市社会发展重点项目(2016108101031)~~

摘　　要：目的观察中老年人群血清hs-CRP、基质金属蛋白酶9(MMP-9)、基质金属蛋白酶组织抑制剂1(TIMP-1)水平与颈动脉斑块稳定性的关系。方法对120例中老年人进行颈动脉超声检查,根据颈动脉斑块性质分为易损斑块组(A组) 45例、稳定斑块组(B组) 41例、无斑块组(C组)34例,并检测各组血清hs-CRP、MMP-9、TIMP-1水平。结果无斑块组、稳定性斑块组及易损斑块组血清hs-CRP、MMP-9水平依次升高,TIMP-1水平依次降低,A、B组患者血清hs-CRP、MMP-9水平均显著高于C组(P <0. 05); A、B组患者血清TIMP-1水平显著低于C组(P <0. 05);血清hs-CRP、MMP-9与颈动脉斑块的不稳定性呈正相关,TIMP-1与颈动脉斑块的不稳定性呈负相关;血清hs-CRP、MMP-9、TIMP-1均是影响颈动脉斑块稳定的独立危险因素(P <0. 05)。结论血清hs-CRP、MMP-9、TIMP-1水平与颈动脉斑块的稳定性密切相关,hs-CRP和MMP-9升高增加颈动脉斑块的风险,TIMP-1升高降低颈动脉斑块的风险。Objective To study on the relationship between the serum level of highsensitivity c-reaction protein （hs-CR）, matrix metalloproteinase 9 （MMT-9）, tissue inhibitor of metalloproteinase 1 （TIMP-1） and carotid plaque stability in elderly people. Methods According to the carotid ultrasonogra- phy examination, 120 old people were divided into vulnerable plaque group （group A, n = 45） , stable plaque group （ group B, n = 41 ） and no plaque group （ group C, n = 34 ） , and serum levels of hs-CRP, MMP-9, TIMP-1 in each group were also detected. Results The serum levels of hs-CRP and MMP-9 of unstable plaque group and stable plaque group were higher than those of non-plaque group （ P 〈 0. 05 ）. hs- CRP and MMP-9 were positively correlated with carotid plaque unstability, while TIMP-1 was negatively correlated with carotid plaque unstability, hs-CRP, MMP-9 and TIMP-1 were independent risk factors for carotid plaque stability. Conclusions Serum levels of hs-CRP, MMP-9 and TIMP-1 are closely related to the stability of carotid plaque. Elevated levels of hs-CRP and MMP-9 increase the risk of carotid plaque, and elevated levels of TIMP-1 decrease the risk of carotid plaque.

关 键 词：颈动脉疾病/代谢 动脉粥样硬化/代谢 C反应蛋白质/代谢 基质金属蛋白酶9/代谢 金属蛋白酶1组织抑制剂/代谢 

分 类 号：R543.4[医药卫生—心血管疾病]