Klotho蛋白对慢性肾脏病钙磷代谢的影响  

Effect of Klotho protein on calcium and phosphorus metabolism in chronic kidney disease

作　　者：徐艳 徐耀 刘昌华 Xu Yan;Xu Yao;Liu Changhua(Department of Nephrology,Jiangsu Province Subei People＇s Hospital,Yangzhou University Clinical Medicine College,Yangzhou 225009,China)

机构地区：[1]江苏省扬州大学临床医学院江苏省苏北人民医院肾内科,225009

出　　处：《中国医师杂志》2018年第10期1594-1597,共4页Journal of Chinese Physician

摘　　要：慢性肾脏病(CKD)发病率逐渐升高,而慢性肾脏病患者随着其肾功能下降逐渐出现顽固性高血压、贫血、营养不良、钙磷代谢紊乱、微炎症状态等并发症严重影响患者生存及预后,其中钙磷代谢紊乱是较常见的并发症,可导致患者心血管病变高发及死亡率增加。近年来研究表明Klotho蛋白具有抗炎、抗氧化应激、抗凋亡及抑制纤维化的作用,可抑制CKD患者肾脏纤维化并调节钙磷代谢紊乱。本文对Klotho蛋白的钙磷代谢调节作用进行综述。The incidence of chronic kidney disease （CKD） gradually increased. With the decline of renal function, CKD patients gradually appear intractable hypertension, anemia, malnutrition, calcium and phosphorus metabolic disorders, micro-inflamnmtory State and other complications which can seriously affect the survival and prognosis. Among them, calcium and phosphorus metabolism disorders are more com- mon complications, and can lead to high incidence of cardiovascular disease and increased mortality. Recent studies have shown that Klotho protein has anti-inflammatory, anti-oxidative stress, anti-apoptosis and anti- fibrosis effects. It can inhibit renal fibrosis and regulate calcium and phosphorus metabolism disorders in pa- tients with CKD. This article reviews the regulatory role of Klotho protein in calcium and phosphorus metabolism.

关 键 词：葡糖醛酸糖苷酶 肾疾病 钙/代谢 磷/代谢 综述 

分 类 号：R692[医药卫生—泌尿科学]