健康体检人群幽门螺杆菌感染与代谢综合征的相关性研究  

Correlation between Helicobacter Pylori Infection and Metabolic Syndrome in Health Examination Subjects

作　　者：雷映红[1] 陈辉[1] 刘菊[1] 李秀娟[1] 刘靖[1] 张琼[1] 王帆[1] LEI Ying-hong;CHEN Hui;LIU Ju;LI Xiu-juan;LIU Jing;ZHANG Qiong;WANG Fan(Department of Geriatrics,Wuhan No.1 Hospital,Wuhan 430022,China)

机构地区：[1]武汉市第一医院老年病科,武汉430022

出　　处：《实用临床医学（江西）》2018年第9期4-6,10,共4页Practical Clinical Medicine

基　　金：武汉市卫计委科研基金(WZ15A04)

摘　　要：目的探讨健康体检人群幽门螺杆菌(HP)感染与代谢综合征(MS)的相关关系。方法选取718例健康体检者,计算体质指数(BMI),测量血压,检测空腹血糖(FBG)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C),用C13呼气实验测定HP,分析健康体检人群HP感染与MS的相关关系。结果 718例健康体检者中诊断MS者94例(13.1%),其中≥60岁者64例,占总MS人群的68.1%;诊断HP感染者240例(33.4%),其中≥60岁者155例,占总HP感染人群的64.6%;MS合并HP感染者42例(5.8%)。与非MS人群相比,MS人群BMI、SBP、DBP、TG、TC均偏高(P<0.05),HDL-C偏低(P<0.05);MS人群中HP感染阳性率高于非MS人群(P<0.05)。≥60岁者中,MS人群HP感染阳性率高于非MS人群(P<0.05);<60岁者中,MS人群HP感染阳性率与非MS人群比较差异无统计学意义(P>0.05)。健康体检人群中,HP感染与MS呈正相关(r=0.092,P=0.013),其中≥60岁者HP感染与MS呈正相关(r=0.094,P=0.040),而<60岁者HP感染与MS无相关性(r=0.091,P=0.158)。结论健康体检人群中HP感染与MS有关,HP感染可能参与MS的发生发展过程,而年龄在该过程中可能起着重要作用。Objective To investigate the relationship between Helicobacter pylori（HP） infection and metabolic syndrome（MS） in physical examination subjects. Methods The body mass index（BMI）,blood pressure,and levels of fasting blood-glucose（FBG）,total cholesterol（TC）,triglyceride（TG）,low-density lipoprotein cholesterol（LDL-C） and high-density lipoprotein cholesterol（HDL-C）were measured in 718 health examination subjects.C13 breath test was used to detect HP infection.The correlation of HP infection and MS was analyzed. Results Among the 718 subjects,MS was diagnosed in 94（13.1%,of whom 64（68.1%） were aged 60 years and older）,HP infection in 240（33.4%,of whom 155（64.6%） were aged 60 years and older）,and MS complicated by HP infection in 42（5.8%）.Compared with those without MS,the BMI,systolic blood pressure,diastolic blood pressure and levels TG and TC increased but levels of HDL-C decreased in subjects with MS（ P 〈0.05）.Among people aged 60 years and older,HP infection rate in MS subjects was higher than that in non-MS subjects（ P 〈0.05）.Among persons younger than 60 years,no significant difference was found between MS and non-MS subjects（ P 〉0.05）.There was a positive correlation between HP infection and MS in these physical examination subjects（ r =0.092, P = 0.013 ）.HP infection was positively associated with MS in people aged 60 years and older（ r = 0.094 , P = 0.040 ）,but was not related to MS in persons younger than 60 years（ r =0.091, P = 0.158 ）. Conclusion There is a relationship between HP infection and MS in physical examination people,suggesting that HP infection is involved in the development of MS.The age may play an important role in this process.

关 键 词：代谢综合征 幽门螺杆菌 胰岛素抵抗 健康体检人群 

分 类 号：R194.3[医药卫生—卫生事业管理]