消瘿方对微波消融术后甲状腺结节的影响  

Effect of Xiaoyingfang on thyroid nodules after microwave ablation

作　　者：贡翊斐 王小平[1] 沈睿[1] 杨晓英[1] 王群[1] 蔡惠群[1] 张宇[1] 陈奎铭 董丽琴[1] GONG Yifei;WANG Xiaoping;SHEN Rui;YANG Xiaoying;WANG Qun;CAI Huiqun;ZHANG Yu;CHEN Kuiming;DONG Liqin(Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai 200071,China)

机构地区：[1]上海中医药大学附属市中医医院,上海200071

出　　处：《现代中西医结合杂志》2018年第33期3649-3652,共4页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：上海市科委医学引导类(中;西医)科技支撑项目(17401933400);上海市卫生和计划生育委员会科研课题(201640034);上海中医药大学预算内项目(2016YSN56)

摘　　要：目的观察微波消融术后中药消瘿方定向透药与口服对患者甲状腺结节的影响。方法将90例实施微波消融术治疗甲状腺结节患者随机分为3组,对照组30例术后仅随访,透药组30例给予消瘿方外用敷贴制剂定向透药治疗,口服组30例给予消瘿方汤剂口服。3组分别于术前、术后检查甲状腺功能及彩超,并记录并发症及不良反应发生情况。结果 3组术后1个月、3个月、6个月、9个月、12个月甲状腺结节最大直径及体积均逐渐缩小(P均<0. 05),且透药组及口服组各时间点甲状腺结节最大直径、体积均明显小于对照组(P均<0. 05),体积缩小率均明显高于对照组(P均<0. 05),且透药组改善情况均明显优于口服组(P均<0. 05)。整个研究过程3组均未发生严重并发症,未出现全身或局部不良反应。结论中药消瘿方可促进微波消融术后甲状腺结节的吸收,其中定向透药法疗效更好,且操作简便,患者依从性好。Objective It is to observe the effect of directional permeate and oral administration of Xiaoyingfang on thyroid nodules after microwave ablation.Methods Ninety patients with thyroid nodule treated by microwave ablation were randomly divided into 3 groups. Thirty cases in the control group were followed up only after operation, and 30 cases in the permeate group were treated with xiaoyingfang plaster to directional permeate drug therapy in external application, and 30 cases in the oral group were given Xiaoyingfang decoction to oral administration. The thyroid function and color Doppler ultrasonography were observed in the three groups before and after operation, and the complications and adverse reactions were recorded.Results The maximum diameter and volume of thyroid nodules were decreased gradually at 1 month, 3 months, 6 months, 9 months and 12 months after operation （all P 〈0.05）, and the maximum diameter and volume of thyroid nodules in the permeate group and the oral group were significantly smaller than those in the control group （all P 〈0.05）, the volume reduction rate was significantly higher than that of the control group （all P 〈0.05）, and the improvements of the permeate group were significantly better than those in the oral group （ P 〉0.05）. There was no serious complications, and was no systemic or local adverse reactions in the 3 groups.Conclusion Xiaoyingfang can promote the absorption of thyroid nodules after microwave ablation, directional permeate drug therapy method is easy to operate is easy to operate, and has good compliance.

关 键 词：甲状腺结节 微波消融术 消瘿方 中药口服 中医定向透药法 

分 类 号：R581.3[医药卫生—内分泌]