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作 者:袁剑峰[1] 张志勇[1] YUAN Jian-feng;ZHANG Zhi-yong(Department of Infectious Disease,Hubei East Medical Group Huangshi City Central Hospital,Affiliated Hospital of Hubei Institute of Technology,Huangshi Hubei 435000,China)
机构地区:[1]鄂东医疗集团湖北省黄石市中心医院、湖北理工学院附属医院感染科,435000
出 处:《蚌埠医学院学报》2018年第9期1166-1168,1172,共4页Journal of Bengbu Medical College
摘 要:目的:探讨中脑星形胶质细胞源性神经营养因子(MANF)蛋白水平与慢性乙型肝炎肝纤维化的相关性。方法:选取慢性乙型肝炎病人87例和健康志愿者80名,采用酶联免疫吸附法检测外周血MANF蛋白水平,同时对慢性乙型肝炎病人进行肝脏穿刺病理学检查。结果:87例慢性乙型肝炎病人中,肝纤维化程度S0~S1有21例,S2有35例,S3~S4有31例;炎症活动度G1有20例,G2有25例,G3有23例,G4有19例;慢性乙型肝炎病人外周血MANF蛋白水平为(2. 51±0. 56) mg/m L,显著高于健康志愿者的(1. 43±0. 32) mg/m L(P <0. 01);肝纤维化程度S3~S4患者外周血MANF蛋白明显高于S2和S0~S1病人(P <0. 01);炎症活动度G2、G3和G4病人外周血MANF蛋白明显高于G1病人(P <0. 05~P <0. 01);慢性乙型肝炎病人外周血MANF蛋白与肝纤维化程度、炎症活动度呈显著正相关(rs=0. 448和rs=0. 324,P <0. 05)。结论:MANF蛋白水平与慢性乙型肝炎病人肝纤维化程度呈正相关。Objective: To investigate the relationship between the level of mesencephalic astrocyte-derived neurotrophic factor(MANF) protein and hepatic fibrosis in patients with chronic hepatitis B.Methods: The levels of MANF protein in peripheral blood of 87 patients with chronic hepatitis B and 80 healthy volunteers were detected using enzyme-linked immunosorbent assay,and the liver biopsy in patients with chronic hepatitis B was examined.Results: Among 87 patients with chronic hepatitis B,the liver fibrosis degree S0 to S1,S2 and S3 to S4 in 21 cases,35 cases and 31 cases were identified,respectively,and the inflammation activity degree G1,G2,G3 and G4 in 20 cases,25 cases,23 cases and 19 cases were found,respectively.The MANF protein level in peripheral blood of patients with chronic hepatitis B[(2.51±0.56)mg/mL] was significantly higher than that in healthy volunteers[(1.43±0.32)mg/mL]( P 〈 0.01 ).The MANF protein level in patients with liver fibrosis degree S3 to S4 was significantly higher than that in patients with liver fibrosis degree S2 and S0 to S1( P 〈0.01).The MANF protein levels in patients with inflammatory activity degree G2,G3 and G4 were significantly higher than that in patients with inflammatory activity degree G1( P 〈0.05 to P 〈0.01).The MANF protein level in peripheral blood of patients with chronic hepatitis B was positively correlated with the degree of liver fibrosis and inflammatory activity degree( r s =0.448 and 0.324, P 〈0.05).Conclusions: The level of MANF protein is positively correlated with the hepatic fibrosis degree in patients with chronic hepatitis B.
关 键 词:慢性乙型肝炎 中脑星形胶质细胞源性神经营养因子 肝纤维化 炎症活动度
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