外周血嗜酸性粒细胞与慢性阻塞性肺疾病的诊疗及预后相关性分析  

Correlation between peripheral blood eosinophils and the diagnosis and prognosis of chronic obstructive pulmonary disease

作　　者：尚晓霞 刘金丽[1] 李佳[1] 王春波[1] 唐颖[1] 慕丽娜[1] Shang Xiaoxia;Liu Jinli;Li Jia;Wang Chunbo;Tang Ying;Mu Lina(Department of Respiratory Medicine,Longnan Hospital,Daqing,Heilongjiang,163453,China)

机构地区：[1]黑龙江省大庆龙南医院呼吸内科,黑龙江大庆163453

出　　处：《当代医学》2018年第31期19-21,共3页Contemporary Medicine

摘　　要：目的探讨外周中嗜酸性粒细胞在慢性阻塞性肺疾病诊治中的价值以及与预后相关性分析。方法选取本院2016年1月～2017年10月收治的300例慢性阻塞性肺疾病急性加重期患者作为研究对象,根据外周血嗜酸性粒细胞水平(EOS%),将这些病例分为两组。A组:EOS%≤2%,100例,B组:EOS%>2%,200例。分析两组中不同分级的COPD患者所占比例,所有受试者均采静脉血2 ml,通过UniCAP100全自动荧光检测系统对其静脉血进行血嗜酸细胞含量测定。结果两组患者中性粒细胞与淋巴细胞的比值(NLR)和住院天数比较,A组患者NLR水平低于B组,A组患者住院天数少于B组(P<0.05);A组患者出院后1年死亡率低于B组患者(P<0.05)。结论 EOS%≤2%的慢性阻塞性肺疾病急性加重期住院患者NLR水平较低,住院时间较短,出院后1年死亡率低表示了外周血嗜酸性粒细胞水平可能作为判断慢性阻塞性肺疾病预后指标。Objective To investigate the value of peripheral eosinophils in the diagnosis, treatment and prognosis of chronic obstructive pulmonarydisease （COPD）. Methods The 300 COPD patients at acute exacerbation phase were admitted to our hospital during January 2016 to October2017. According to the level of peripheral blood eosinophil （EOS%）, these patients were divided into two groups. Group A： EOS% ≤ 2%（n=100）;Group B： EOS%〉 2% （n=200）. The proportion of patients within different COPD stages in group A and B was analyzed. The eosinophil content wasmeasured by UniCAP100 automatic fluorescence detection system. Results In Group A, the ratio of neutrophil to lymphocyte （NLR）, length ofhospitalstay, and one-year mortality were all lower than those in Group B. Conclusion COPD patients at acute exacerbation stage with EOS%≤2% hadlower NLR levels and shorter hospital stay. Lower one-year mortality indicated that peripheral blood eosinophil levels may potentially serve as aprognostic indicator of COPD.

关 键 词：血嗜酸细胞 慢性阻塞性肺疾病 预后分析 

分 类 号：R563.9[医药卫生—呼吸系统]