调脂合剂对慢性丙型肝炎病毒感染合并脂肪肝患者脂质代谢紊乱的影响  

Effects of Tiaozhi mixture on lipid metabolism disorder in patients with chronic hepatitis C virus infection complicated with fatty liver

作　　者：李竞 缪萍 黄涓涓 陈贤峰 王建勇 Li Jing;Miu Ping;Huang Juanjuan;Chen Xianfeng;Wang Jianyong(Department of Traditional Chinese Medicine,Ningbo Yinzhou People＇s Hospital,Ningbo 315040,China)

机构地区：[1]宁波市鄞州人民医院中医科,315040

出　　处：《中华实验和临床病毒学杂志》2018年第5期525-528,共4页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的探讨调脂合剂对慢性丙型肝炎病毒感染合并脂肪肝患者脂质代谢紊乱的影响。方法回顾性分析鄞州人民医院2016年1月至2017年1月收治的122例慢性丙型肝炎病毒感染合并脂肪肝患者临床资料，对照组仅接受抗病毒治疗，观察组接受抗病毒治疗同时增用调脂合剂。统计两组患者治疗前后各项血脂指标、HCVRNA载量下降情况、血清抗-HCV转阴率、肝功能指标及不良反应发生情况。结果治疗后，两组患者血脂TG、TC、LDL-C水平明显下降且观察组血脂TG、TC、LDL-C水平下降幅度大于对照组；观察组患者血脂HDL—C水平上升明显，对照组患者血脂HDL-C水平基本无变化；两组患者肝功能ALT、TBA水平检测结果均有效降低且观察组降低幅度大于对照组，两组患者肝功能AST水平均有降低但组间差异无统计学意义；观察组HCVRNA载量下降情况、血清抗-HCV转阴率高于对照组；治疗后两组患者不良反应发生率差异无统计学意义（x^=0．000，P=1．000）。结论对慢性丙型肝炎病毒感染合并脂肪肝患者临床治疗中配合调脂合剂可有效增加抗病毒疗效，降低不良反应发生可能，帮助患者恢复肝功能，安全性高，值得临床推广。Objective To investigate the effects of Tiaozhi mixture on lipid metabolism disorder in patients with chronic hepatitis C virus infection and fatty liver. Methods The clinical data of 122 cases of patients with chronic hepatitis C virus infection and fatty liver admitted to our hospital from January 2016 to January 2017 were retrospectively analyzed. Control group was only given antiviral treatment, and observation group was given antiviral treatment and Tiaozhi mixture. The blood lipids parameters, decrease of HCV RNA load, negative conversion rate of serum anti-HCV. Results After treatment, the levels of blood lipids, i. e. , triglycerides （TG） , total cholesterol （TC） and low density lipoprotein-cholesterol （LDL-C） were decreased significantly in the two groups, and the decreases of blood lipid levels of TG, TC and LDL-C in observation group were greater than those in control group. The level of high density lipoprotein-colesterol （HDL-C） was increased significantly in observation group, and the level of HDL-C in control group was basically unchanged. The liver function tests for alanine aminotransferase （ALT） and total bile acid （TBA） levels were all decreased effectively, and the decrease in observation group was greater than that in control group, and the aspartate aminotransferase （AST） level in the two groups was reduced, but there was no significant difference between the two groups. The decrease of HCV RNA load and negative conversion rate of serum anti-HCV in observation group were higher than those in control group. There was no significant difference in the incidence rate of adverse reactions between the two groups after treatment（x^2 = 0. 000,P = 1,000）, Concluaions In the clinical treatment of chronic hepatitis C virus infection with fatty liver, combined Tiaozhi mixture can effectively increase the antiviral efficacy, reduce the possibility of adverse reactions, and help patients with liver function recovery, and it has high safety. Thus it is worthy of clinical pro

关 键 词：肝炎 丙型 慢性 脂肪肝 调脂合剂 

分 类 号：R285[医药卫生—中药学]