腹膜透析治疗对先天性心脏病患儿术后血清因子水平及预后的影响  

Clinical Efficacy of Peritoneal Dialysis in Treatment of Congenital Heart Disease in Children and Influence on Serum Factors

作　　者：李雅莉 张波[1] 黄建玲 李智敏 金鑫 LI Ya-li;ZHANG Bo;HUANG Jian-ling;LI Zhi-min;JIN Xin(The 3201 Affiliated Hospital of Medical College of Xi＇an Jiao Tong University,Hanzhong,Shaanxi,723000,China)

机构地区：[1]西安交通大学医学院附属三二0一医院,陕西汉中723000

出　　处：《现代生物医学进展》2018年第18期3514-3517,共4页Progress in Modern Biomedicine

基　　金：陕西省科技攻关项目资助(2007K13-03)

摘　　要：目的:探讨腹膜透析治疗对先天性心脏病患儿术后血清因子水平及预后的影响。方法:选择2013年11月～2016年11月我院收治的96例小儿先天性心脏病,按治疗方式分为对照组与研究组,每组48例,两组均接受手术治疗。对照组于术后采用常规治疗,研究组在常规治疗基础上加以腹膜透析治疗,观察并比较两组治疗前后血清β2微球蛋白、24 h尿蛋白、血尿素氮、血肌酐、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、碳酸氢盐、钙离子、钾离子水平的变化及死亡情况。结果:治疗后,两组血清β2微球蛋白、24 h尿蛋白、血尿素氮、血肌酐、IL-6、IL-8、TNF-α、钾离子水平均较治疗前显著降低,且研究组以上指标均明显低于对照组;两组碳酸氢盐、钙离子水平均较治疗前明显上升,且研究组以上指标明显高于对照组(P<0.05)。此外,研究组死亡率明显低于对照组(P<0.05)。结论:腹膜透析治疗先天性心脏病患儿术后能够降低病死率,改善肾功能、炎症因子及电解质平衡紊乱。Objective：To research the effect of peritoneal dialysis on the serum factors and prognosis of children with congenital heart diseas.Methods：96 children with congenital heart disease from November 2013 to November 2016 were divided into the control group and the research group according to the treatment mode,with 48 cases in each group.Both groups were treated with surgery,the control group was treated with routine treatment after surgery,while the research group was treated with peritoneal dialysis based on the control group.The serum β2-microglobulin,24 h urine protein,blood urea nitrogen,blood creatinine,interleukin 6（IL-6）,interleukin 8（IL-8）,tumor necrosis factor-α（TNF-α）,hydrocarbonate,calcium,potassium levels and mortality were observed and compared between two group.Results：After treatment,the serum β2-microglobulin,24 h urine protein,blood urea nitrogen,blood creatinine,IL-6,IL-8,TNF-α,potassium levels of two group were decreased,which were obviously lower in the research group than those of the control group,the bicarbonate,calcium ions of two group were obviously increased,which were significantly higher in the research group than those of the control group（P〈0.05）.The mortality rate of research group was lower than that of the control group（P〈0.05）.Conclusion：Peritoneal dialysis can decrease the mortality of congenital heart disease children after operation,which regulate the serum factors,improve the kidney function,inflammation factor and electrolyte balance disorder.

关 键 词：小儿 先天性心脏病 术后腹膜透析 临床疗效 血清因子 

分 类 号：R541.1[医药卫生—心血管疾病] R459.5[医药卫生—内科学]