普瑞巴林、加巴喷丁联合神经阻滞治疗带状疱疹后神经痛的临床疗效比较  

Comparison of the Curative Effect of Pregabalin,Gabapentin Combined with Never Blocking Respectively on the Postherpetic Neuralgia

作　　者：刘美义[1] 孙玉亮 黎环[1] 张亚清[1] 段宝霖[1] LIU Mei-yi;SUN Yu-liang;LI Huan;ZHANG Ya-qing;DUAN Bao-lin(Department of pain,Qinghai provincial people＇s hospital,Xining,Qinghai,810007,China)

机构地区：[1]青海省人民医院疼痛科,青海西宁810007

出　　处：《现代生物医学进展》2018年第18期3572-3575,共4页Progress in Modern Biomedicine

基　　金：青海省科学技术厅基金项目(2016-ZJ-797)

摘　　要：目的:比较普瑞巴林、加巴喷丁联合神经阻滞治疗带状疱疹后神经痛(PHN)的临床疗效。方法:选择2014年8月至2016年11月我院门诊收治的带状疱疹后神经痛患者80例,并将其随机分为两组,每组40例。A组患者接受普瑞巴林联合神经阻滞治疗,B组患者接受加巴喷丁联合神经阻滞治疗,比较两组患者治疗前后的视觉疼痛模拟(VAS)评分、失眠严重程度指数(ISI)评分、生活质量满意指数(LSIB)评分及治疗期间不良反应的发生情况。结果:A组患者治疗后4、7、14 d的VAS评分均显著低于B组(P<0.05),LSIB评分显著高于B组(P<0.05),A组患者治疗后4、7 d的ISI评分均显著低于B组(P<0.05);A组发生不良反应的总发生率显著低于B组(P<0.05)。结论:普瑞巴林联合神经阻滞治疗PHN缓解疼痛和失眠的效果显著优于巴喷丁联合神经阻滞治疗,其可显著提高患者的生活质量,并减少不良反应。Objective：To compare the curative effect of pregabalin,gabapentin combined with never blocking on the postherpetic neuralgia（PHN）.Methods：80 cases of patients with postherpetic neuralgia were collected in our hospital from August 2014 to November2016,they were randomly divided into two groups.Group A（n=40） was given pregabalin combined with never blocking treatment,and Group B was given gabapentin combined with never blocking.The visual analogue score（VAS）,insomnia severity index（ISI） score and life satisfaction index B（LSIB） score before and after treatment and the incidence of adverse reactions during the treatment were compared between two groups.Results：On the 4 th,7 th,14 thday after treatment,the VAS scores of patients in Group A were significantly lower than those patients in Group B（P〈0.05）,while the LSIB score were significantly higher（P〈0.05）.On the 4 th,7 thday after treatment,the ISI score of Group A were lower than those of Group B（P〈0.05）.The incidence of adverse reactions in Group A was significantly lower than that of Group B（P〈0.05）.Conclusions：Pregabalin combined with never blocking had better clinical efficacy in the treatment of PNH than gabapentin combined with never blocking,it not only significantly relieved pain and insomnia,but also increased the quality of life and decreased the incidence of adverse reactions.

关 键 词：带状疱疹后神经痛 神经阻滞 普瑞巴林 疗效 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]