抗A型流感病毒广谱中和抗体及广谱通用疫苗研究进展  

Research progress in broad neutralizing antibodies and universal vaccines against influenza A virus

作　　者：冯道斌 刘明斌 张晓燕[2] 徐建青[2] Feng Daobin;Liu Mingbin;Zhang Xiaoyan;Xu Jianqing(Department of Epidemiology and Health Biostatistics,School of Public Health,Nanchang 330006,China Feng Daobin;Shanghai Public Health Clinical Center Affiliated to Fudan University,Shanghai 201508,China（Feng Daobin,Liu Mingbin,Zhang Xiaoyan,Xu Jianqing)

机构地区：[1]南昌大学公共卫生学院流行病与卫生统计学系,330006 [2]复旦大学附属公共卫生临床中心,上海201508

出　　处：《中华微生物学和免疫学杂志》2018年第10期782-789,共8页Chinese Journal of Microbiology and Immunology

基　　金：国家自然科学基金项目（81660339,81761128007）

摘　　要：接种流感疫苗是预防和控制流感流行的最有效手段，可诱导广谱、长期保护作用的通用流感疫苗研究尚处于初级阶段。现已鉴定报道了几个广谱中和抗体可以抵抗多种A型流感病毒，病毒表面抗原血凝素（haemagglutinin，HA）与抗体的复合物品体结构揭示了至少3个高度保守表位。深入了解中和抗体与抗原互作分子机制可以为合理设计通用流感疫苗提供新策略，同时对开发新的抗流感病毒治疗抗体药物也具有重要启示意义。本文综述了A型流感病毒广谱中和抗体和广谱通用疫苗的研究进展。Influenza vaccination is the most effective means to prevent and control influenza epi-demics, and the universal influenza vaccine which can induce broad and long-term protective effect is still in its infancy. Up to date, several broad neutralizing antibodies that can antagonize a variety of influenza A vi-ruses have been identified, and the crystal structure of the antibody and HA complex reveals at least three highly conserved epitopes. Deep insights into the molecular mechanism of the interactions between neutrali-zing antibodies and virus antigen can elicit a new strategy not only for rational design of universal influenza vaccines, but also for the development of antibody-based therapeutics against influenza virus. In this paper, advances in research of universal neutralizing antibodies and vaccines for Influenza A virus are reviewed.

关 键 词：A型流感病毒 血凝素 表位 广谱中和抗体 疫苗 

分 类 号：R392[医药卫生—免疫学]