人肝CYP450酶含量与活性研究进展  

Research Progress in the Content and Activity of Cytochrome P450 in Human Liver

作　　者：高洁 乔海灵[1] GAO Jie;QIAO Hailing(Institute of Clinical Pharmacology,Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学临床药理研究所,河南郑州450052

出　　处：《药学进展》2018年第8期564-573,共10页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金(No.81473279;No.81673507)

摘　　要：肝脏药物代谢是药物动力学的重要环节,细胞色素P450(CYP450)是肝脏的主要药物代谢酶,参与临床70%～80%常用药物的代谢。CYP450酶含量、活性的个体差异是导致药物效应存在个体差异的主要原因。笔者结合所在课题组的新近研究结果和相关文献,对人肝CYP450酶的生理含量、活性及其个体差异、CYP450系统表型的变化过程以及酶含量和基因多态性等对药物代谢的影响研究进展进行综述,以期为相关临床研究提供参考。Hepatic drug metabolism is a vital part of pharmacokinetics. Cytochrome P450 oxidase（CYP450） is the major drug metabolic enzyme in liver that is involved in the metabolism of 70%～80% of commonly used drugs in the clinic. Individual differences in the content and activity of CYP450 enzyme are the main causes of individual differences in drug effects. Based on the author＇s recent research results and literature reports, the effects of physiological content, activity and individual differences of human liver CYP450 enzyme, phenotype changes of CYP450 system, enzyme content and gene polymorphism on drug metabolism were reviewed, so as to provide reference for related clinical study.

关 键 词：细胞色素P450氧化酶 含量 活性 个体差异 基因多态性 

分 类 号：R969.1[医药卫生—药理学]