过氧化物还原酶2及其潜在的临床应用价值研究进展  

Research Progress of Peroxiredoxin 2 and Its Potential in Clinical Applications

作　　者：王丽敏 杜诗琦 王佳凤[1] 李博[1] 狄斌[1] WANG Limin;DU Shiqi;WANG Jiafeng;LI Bo;DI Bin(Department of Pharmaceutical Analysis,Key Laboratory on Protein Chemistry and Structural Biology,MOE Key Laboratory of Drug Quality Control and Pharmacovigilance,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]中国药科大学药物分析系蛋白质化学与结构生物学重点实验室药物质量与安全预警教育部重点实验室,南京210009

出　　处：《中国现代应用药学》2018年第10期1573-1579,共7页Chinese Journal of Modern Applied Pharmacy

基　　金：中央高校基本科研业务费专项资金资助(2632017ZD07)

摘　　要：过氧化物还原酶2(peroxiredoxins,Prx2)是过氧化物还原酶家族的重要一员,在人体多种组织器官中都有表达,红细胞内含量极其丰富。Prx2在清除过氧化物、信号转导、分子伴侣等方面发挥着重要作用。Prx2结构和表达量的改变与多种疾病直接相关,是临床诊断及药物开发领域的新关注点。本文从Prx2的生理功能及其与不同疾病的相关性、不同存在形式、Prx2的检测手段3个方面进行综述,为进一步探究Prx2与疾病调控机制及其在疾病诊断和潜在临床应用的研究方面提供参考。Peroxiredoxin 2（Prx2） is an important member of peroxiredoxin family. It is widely distributed in various tissues and organs of human body, especially abundant in erythrocytes. Prx2 can function as a scavenger of peroxide, sensor and transducer of cell signals, molecular chaperone and so on. Changes in the structure and expression of Prx2 are related to many human diseases, consequently making Prx2 a new focus in clinical diagnosis and drug development. This review generally introduced the physiological functions of Prx2 and its relation with different human diseases, as well as detecting techniques of Prx2 in different forms. It aims to study the regulation mechanism of Prx2 and its potential in disease diagnosis and other clinical applications.

关 键 词：过氧化物还原酶2 生理功能 检测方法 临床应用 

分 类 号：R969.3[医药卫生—药理学]