清热解毒化痰汤对晚期胃癌术后痰毒瘀结证患者生活质量的影响  

Effects of qingre jiedu huatan decoction on the quality of life in the patients of the phlegm-toxin-stasis stagnation syndrome after the advanced gastric cancer surgery

作　　者：张凡勇[1] 张娜[1] 方亮[1] ZHANG Fan- yong,ZHANG Na,FANG Liang(Department of Gastrointestinal Surgery, Huanggang Center Hospital, Huanggang Huangbei 438000)

机构地区：[1]黄冈市中心医院胃肠外科,湖北黄冈438000

出　　处：《世界中西医结合杂志》2018年第9期1286-1289,1317,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：湖北省自然科学基金资助项目(2013FFB043)

摘　　要：目的探讨清热解毒化痰汤对晚期胃癌术后痰毒瘀结证患者生活质量的影响。方法选取2013年10月至2016年4月我院100例胃癌术后痰毒瘀结证患者,随机数字表法分为对照组与治疗组,各50例。两组术后均给予常规化疗措施,在此基础上对照组联合采用盐酸氨溴索片+福多司坦胶囊,治疗组采用清热解毒化瘀汤治疗,两组均持续治疗2个疗程。统计对比两组入院时及疗程结束后生活质量评分、血清炎性因子[白细胞介素-6(Interleukin-6,IL-6)、IL-8、肿瘤坏死因子-α(Tumor necrosis factorα,TNF-α)、C反应蛋白(C-reactive protein,CRP)]及脂质代谢指标[高密度脂蛋白(High density lipoprotein,HDL)、甘油三酯(Triacylglyceride,TG)、总胆固醇(Total cholesterol,TC)]变化情况及不良反应发生率,并评价两组机体功能状态优良率。结果治疗后两组社会功能、情绪功能、认知功能、角色功能、躯体功能评分较治疗前增高,且治疗组高于对照组,差异有统计学意义(P<0.05);治疗后两组血清IL-6、IL-8、TNF-α、CRP水平较治疗前降低,且治疗组低于对照组,差异有统计学意义(P<0.05);治疗后两组脂质代谢指标均较治疗前改善,且治疗组HDL高于对照组,TG、TC低于对照组,差异有统计学意义(P<0.05);两组机体功能状态优良率比较,治疗组90.0%(45/50)高于对照组66.0%(33/50),差异有统计学意义(P<0.05);两组不良反应发生率比较,治疗组12.0%(6/50)低于对照组32.0%(16/50),差异有统计学意义(P<0.05)。结论晚期胃癌术后痰毒瘀结证患者采用清热解毒化瘀汤效果显著,可有效改善其脂质代谢状态及血清炎性因子水平,提高机体功能及生活质量,且具有一定安全性。Objective To explore the effects of qingre jiedu huatan decoction on the quality of life（ QOL） in the patients of the phlegm-toxin-stasis stagnation syndrome after the advanced gastric cancer surgery. Methods A total of100 patients of the phlegm-toxin-stasis stagnation syndrome after the advanced gastric cancer surgery were collected from October 2013 to April 2016 in the Hospital. According to the random number tables,a control group and a treatment group were divided,50 cases in each one. After surgery,the routine chemotherapy was given in the two groups. Additionally,in the control group,ambroxol hydrochloride tablets and fudosteine capsules were adopted; and in the treatment group,qingre jiedu huatan decoction was used. The treatment lasted for 2 courses in the two groups. The QOL scores at the moment of hospital admission and at the end of treatment,the levels of IL-6,TNF-α,CRP,HDL,TG and TC,as well as the incidence of adverse reaction were compared statistically between the two groups. The effective rate of the body function was evaluated in the two groups. Results After treatment,the scores of social function,emotional function,cognitive function,role function and somatic functions were increased as compared with those before treatment in the two groups,and the increases in the treatment group were higher than the control group,indicating the significant differences（ P〈0. 05）. After treatment,the levels of IL-6,TNF-α and CRP were reduced as compared with those before treatment in the two groups,and the results in the treatment group were lower than the control group,indicating the significant differences（ P〈0. 05）.The lipid metabolism indexes after treatment were improved as compared with those before treatment in the two groups.HDL in the treatment group was higher than the control group and TG and TC were lower than the control group,indicating the significant differences（ P〈0. 05）. Regarding the effective rate of body function,it was 90. 0%（ 45/50） in the treatment group,high

关 键 词：晚期胃癌 痰毒瘀结证 清热解毒化痰汤 生活质量 脂质代谢 炎性因子 机体功能状态 

分 类 号：R273[医药卫生—中西医结合]