聚乙烯醇微球的制备与表征  

Preparation and Characterization of Polyvinyl Alcohol Microspheres

作　　者：廖囡囡[1,2] 杨旭霞 吴丽娟 陈丽[1,2] 杨光 吴昌琳[1,2] LIAO Nannan;YANG Xuxia;WU Lijuan;CHEN Li;YANG Guang;WU Changlin(Shanghai Key Laboratory of Magnetic Resonance,School of Physics and Materials Science,East China Normal University,Shanghai 200062,China;Suzhou Novovita Bio-Products Co.Ltd.,Suzhou 215300,China)

机构地区：[1]华东师范大学物理与材料学院上海市磁共振重点实验室,上海200062 [2]苏州博创同康生物工程有限公司,江苏苏州215300

出　　处：《材料科学与工程学报》2018年第5期764-768,738,共6页Journal of Materials Science and Engineering

摘　　要：采用反相悬浮-化学交联的方法,以聚乙烯醇(Polyvinyl Alcohol,PVA)水溶液为分散相(水相),含有失水山梨醇单油酸酯(Span-80)为表面活化剂的液体石蜡为连续相(油相),三偏磷酸钠(Sodium Trimetaphosphate, STMP)为交联剂,氢氧化钠为催化剂,制备聚乙烯醇交联微球(CPVA)。利用傅里叶变换红外光谱仪(FTIR)和核磁共振波谱仪(NMR)分析交联产物的结构;通过扫描电子显微镜(SEM)观察微球的表面形貌,并分析微球的粒径分布和平均粒径大小;利用表面接触角测量仪测量微球的表面接触角,分析微球的亲水性;并通过公式计算,考察微球表面所含羟基的数量以及微球的溶胀率。结果表明:微球表面含有大量活性羟基;具有较好的亲水性,干燥的微球粒径大致分布在1～20μm,平均粒径为11.5μm;微球在生理盐水中30min达到吸水平衡,且饱和溶胀率为119.6%。在本文中使用无毒的STMP为交联剂,解决了传统依赖于醛类交联剂造成的生物相容性风险问题。因此,该种方法下制备的PVA微球适合于药物缓释系统。Polyvinyl alcohol （PVA） microspheres were prepared via inverse suspension polymerization, using aqueous PVA solution as a dispersed phase （water phase）, liquid paraffin, containing sorbitan monooleateas, as a continuous phase （oil phase）, sodium trimetaphosphate （STMP） as a crosslinker, and sodium hydroxide as a catalyst. The composition, structure, morphology, particle size distribution and hydrophilic property of the microspheres were characterized and observed experimentally. The amount of hydroxyl groups on microspheres surface and the swelling ratio were calculated. The results evidenced a large number of hydroxyl groups and appreciable hydrophilicity on the microspheres surface. The size distribution range of the microspheres from 1 to 20μm, and the average particle size is 11.5μm. The swelling ratio of microsphere is 119.6%. In this article, the use of non-toxic STMP, as crosslinking agent, has solved the biocompatibility risk problem due to traditional aldehyde crosslinking agent. It is concluded that the PVA microspheres are promising for drug sustained-release substrate.

关 键 词：聚乙烯醇 三偏磷酸钠 交联微球 

分 类 号：O622.3[理学—有机化学]