瓜蒌薤白半夏汤治疗冠心病心绞痛(痰浊痹阻)随机平行对照研究  

Randomized Parallel Controlled Study on Gualou Xiebai Banxia Decoction(瓜蒌薤白半夏汤) in Treating Coronary Heart Disease with Angina Pectoris(Phlegm Turbidity Obstruction/痰浊痹阻)

作　　者：寇培军 KOU Peijun(Two Families of the Heart of Jiaxian Hospital of Traditional Chinese Medieine,Pingdingshan 467100,Henan,China)

机构地区：[1]河南省平顶山市郏县中医院心内二科,河南平顶山467100

出　　处：《实用中医内科杂志》2018年第8期32-34,共3页Journal of Practical Traditional Chinese Internal Medicine

摘　　要：[目的]观察瓜蒌薤白半夏汤治疗冠心病心绞痛(痰浊痹阻)疗效。[方法]使用多随机平行对照方法,将128例住院及门诊患者按就诊顺序号方法随机分为两组。对照组64例阿司匹林,100mg/次,1次/d;阿托伐他汀,20mg/次,1次/d,晚上睡前服用;单硝酸异山梨酯,20mg/次,2次/d。治疗组64例瓜蒌薤白半夏汤(黄芪30g,瓜蒌、薤白各20g,茯苓、白术、丹参各为15g,半夏、陈皮各10g),1剂/d,水煎300mL,早晚口服。连续治疗2周为1疗程。观测临床表现、心肌血运重建、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效48例,有效16例,无效4例,总有效率94.12%;对照组显效29例,有效28例,无效11例,总有效率83.82%;治疗组疗效优于对照组(P<0.05)。心肌血运重建两组均有改善(P<0.05),治疗组改善优于对照组(P<0.05,P<0.01)。[结论]瓜蒌薤白半夏汤治疗冠心病心绞痛(痰浊痹阻),疗效满意,无严重不良反应,值得推广。[Objective] To observe the curative effect of Gualu Xielai Banxia decoction on coronary heart disease angina pectoris（phlegm turbidity obstruction）. [Methods] a total of 128 inpatients and outpatients were randomly divided into two groups according to the order of treatment. In the control group, 64 cases of aspirin, 100 mg/times, 1 times/d; atorvastatin, 20 mg/times, 1 times/d, at night before bedtime; isosorbide mononitrate, 20 mg/times, 2 times/d. In the treatment group, 64 cases of Gualou Banxia decoction（Huanqi 30 g,Gualou,Xiebai each 20 g,Fuling,Baizhu,Danshen each 15 g,Banxia,Chenpi each 10 g）, 1 doses of/d, water decocted 300 mL, early and late orally. Continuous treatment for 2 weeks was the 1 course of treatment. Clinical symptoms, myocardial revascularization and adverse reactions were observed. The 1 course of treatment was treated and the curative effect was determined. [Results] 48 cases were found in the treatment group, 16 cases were effective, 4 cases were invalid, the total effective rate was 94.12%, the control group was 29 cases, 28 cases were effective, 11 cases were invalid and the total effective rate was 83.82%. The curative effect of the treatment group was better than the control group（P〈0.05）. The improvement of myocardial revascularization in the treatment group was better than that in the control group（P〈0.05）. [Conclusion] Gualou Xielai Banxia decoction has satisfactory curative effect in treating angina pectoris of coronary heart disease（phlegm turbidity obstruction）, no serious adverse reactions, and is worthy of promotion.

关 键 词：冠心病心绞痛 痰浊痹阻 瓜蒌薤白半夏汤 心肌血运重建 中药复方 中医药治疗 随机平行对照研究 

分 类 号：R259[医药卫生—中西医结合]