弓形虫钙离子结合蛋白的研究进展  

Research progress on calcium-binding protein in Toxoplasma gondii

作　　者：赵旭[1] 张婷[1] 张义伟 王大为[1] 冯颖[1] 杨娜[1] 陈冉 桑晓宇[1] 陈启军[1] 姜宁[1] ZHAO Xu;ZHANG Ting;ZHANG Yi-wei;WANG Da-wei;FENG Ying;YANG Na;CHEN Ran;SANG Xiao-yu;CHEN Qi-jun;JIANG Ning(Animal Husbandry and Veterinary College,Shenyang Agricultural University,Key Laboratory of Liaoning Province,Shenyang 100886,China)

机构地区：[1]沈阳农业大学畜牧兽医学院,辽宁省重点实验室,沈阳100886

出　　处：《中国寄生虫学与寄生虫病杂志》2018年第5期525-528,共4页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：吉林省省级经济结构调整战略调整引导资金专项项目(No.2015Y033)

摘　　要：刚地弓形虫(Toxoplasma gondii)作为顶复门中一种寄生原虫,可以感染有核细胞。研究表明,钙离子与弓形虫侵染、运动等生理活动相关。内质网中含有大量的钙离子,许多钙离子结合蛋白质在弓形虫的生理活动中起重要作用。钙离子结合蛋白质包含多种EF手型(EF-hand)结构域。目前记载在TOXO DB中含有EF-hand的蛋白质有55种;在Plasmo DB含有EF-hand的蛋白质有69种。本文对钙离子结合蛋白质的各种作用进行阐述。Toxoplasma gondii, a type of apicomplexa protozoan parasite, can infect nucleated cells.Studies have shown that Ca^2＋ is associated with physiological activity of Toxoplasma gondii such as infection and movement.Ca^2＋ is abundant in endoplasmic reticulum.There are many calcium-binding proteins important for physiological activity of Toxoplasma gondii.The calcium-binding proteins contain various EF-hand（EF） motifs, and currently there are 55 such proteins according to the records in Toxo DB, and 69 in Plasmo DB.In this review, the roles of Ca^2＋-binding proteins are discussed.

关 键 词：刚地弓形虫 顶复门 钙离子结合蛋白质 

分 类 号：R383.3[医药卫生—医学寄生虫学]