Progress in the mechanism study of long chain noncoding RNA in cardiovascular diseases  

作　　者：代姗姗 魏广和 

机构地区：[1]Jining Medical University [2]Department of Cardiology, the Affiliated Hospital of Jining Medical University

出　　处：《South China Journal of Cardiology》2018年第3期195-201,共7页岭南心血管病杂志（英文版）

摘　　要：Background Long chain noncoding RNA（lncRNA） lacks the ability to encode proteins and is initially considered to be transcriptional noise. Studies have shown that lncRNA is involved in the occurrence and development of many human diseases by regulating gene expression, and more and more evidence have indicated the role of lncRNA in common cardiovascular diseases, including atherosclerosis, myocardial infarction, heart failure, hypertension, aneurysm and so on. This review summarizes the molecular mechanisms of lncRNA in common cardiovascular diseases and provides evidence for exploring new therapeutic targets for these diseases.Background Long chain noncoding RNA（lncRNA） lacks the ability to encode proteins and is initially considered to be transcriptional noise. Studies have shown that lncRNA is involved in the occurrence and development of many human diseases by regulating gene expression, and more and more evidence have indicated the role of lncRNA in common cardiovascular diseases, including atherosclerosis, myocardial infarction, heart failure, hypertension, aneurysm and so on. This review summarizes the molecular mechanisms of lncRNA in common cardiovascular diseases and provides evidence for exploring new therapeutic targets for these diseases.

关 键 词：long noncoding RNA（lncRNA） cardiovascular diseases 

分 类 号：R54[医药卫生—心血管疾病]