四联方案对小儿幽门螺杆菌阳性胃炎近期疗效的研究  

Study on the short-term curative effect of tetralogy regimen in children with Helicobacter pylori positive gastritis

作　　者：周长怀[1] 石光莲[1] Zhou Changhuni, Shi Guanglian(Department of Pediatrics, Northern District, Central Hospital of Ankang City, Shaanxi Ankang 725000, China)

机构地区：[1]陕西省安康市中心医院北院区儿科,725000

出　　处：《中国医师进修杂志》2018年第11期964-967,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨四联方案对小儿幽门螺杆菌（H.pylori）阳性胃炎近期疗效、H.pylori根治率及不良反应的影响。方法选取2015年7月至2017年7月小儿H.pylori阳性胃炎患儿100例，按随机数字表法分为对照组和观察组，每组50例。对照组患儿采用常规三联方案治疗，奥美拉唑、克拉霉素和替硝唑；观察组患儿采用四联方案治疗，即在对照组基础上加用复方嗜酸乳杆菌片。两组患儿均治疗14 d。观察腹痛缓解情况、病理评分、胃镜活检病理表现（炎性活动、嗜酸细胞增多、幽门腺萎缩和淋巴滤泡）治愈率、不良反应及近期疗效。结果观察组腹痛缓解率、H.pylori根治率、近期总有效率及炎性活动、嗜酸细胞增多、幽门腺萎缩和淋巴滤泡治愈率明显高于对照组[96.00%（48/50）比82.00%（41/50）、90.00%（45/50）比72.00%（36/50）、90.00%（45/50）比74.00%（37/50）、70.73%（29/41）比51.16%（22/43）、73.68%（28/38）比50.00%（18/36）、76.67%（23/30）比58.06%（18/31）和53.49%（23/43）比28.89%（13/45）]，病理评分明显低于对照组[（2.15 ± 0.82）分比（4.01 ± 1.33）分]，差异有统计学意义（P〈0.05）。两组不良反应发生率比较差异无统计学意义（P〉0.05）。结论四联方案对小儿H.pylori阳性胃炎可显著缓解相关症状和体征，提高H.pylori根治效果，减轻胃黏膜病理损伤，且未增加药物不良反应。ObjectiveTo investigate the short-term effect, Helicobacter pylori （H.pylori） radical rate and adverse reaction of tetralogy regimen in children with H.pylori positive gastritis.MethodsOne hundred children with H.pylori positive gastritis from July 2015 to July 2017 were selected, and the children were divided into control group and observation group according to the random digits table method with 50 cases in each group. The children in control group were treated with conventional triple regimen （omeprazole, clarithromycin and tinidazole）, and the children in observation group were treated with tetralogy regimen （omeprazole, clarithromycin, tinidazole and eosinophil-lactobacillus compound tablets）. Both groups were treated for 14 d. The abdominal pain remission rate, pathological score, cure rate of pathological findings of gastroscopy biopsy （inflammatory activity, eosinophil proliferation, pyloric gland atrophy and lymphatic follicles）, adverse reaction and short-term effect were observed. ResultsThe abdominal pain remission rate, H.pylori radical rate, short-term total effective rate and the cure rates of inflammatory activity, eosinophil proliferation, pyloric gland atrophy, lymphatic follicles in observation group were significantly higher than those in control group： 96.00% （48/50） vs. 82.00% （41/50）, 90.00% （45/50） vs. 72.00% （36/50）, 90.00% （45/50） vs. 74.00% （37/50）, 70.73% （29/41） vs. 51.16% （22/43）, 73.68% （28/38） vs. 50.00% （18/36）, 76.67% （23/30） vs. 58.06% （18/31） and 53.49% （23/43） vs. 28.89% （13/45）; the pathological score was significantly lower than that in control group： （2.15 ± 0.82） scores vs. （4.01 ± 1.33） scores, and there were statistical differences （P〈0.05）. There was no statistical difference in incidence of adverse reaction between 2 groups （P〉0.05）. ConclusionsTetralogy regimen can significantly relieve the symptoms and signs in children with H.pylori positive gastritis, improve the cura

关 键 词：胃炎 儿童 螺杆菌 幽门 治疗结果 

分 类 号：R725.7[医药卫生—儿科]