中西医结合治疗慢性阻塞性肺疾病伴呼吸肌疲劳的疗效及对血清白细胞介素6、白细胞介素8的影响  

Therapeutic effect of combination of traditional Chinese medicine and western medicine on chronic obstructive pulmonary disease complicated with respiratory muscle fatigue and its effects on serum IL -6 and IL -8

作　　者：何佳 丁雨红 刘洋 He Jia;Ding Yuhong;Liu Yang(First clinical college of Zhejiang University of Chinese Medicine 310053,China;Department of Respiratory Diseases,the Traditional Chinese Medicine Hospital of Keqiao District,Shaoxing,Zhejiang 312030,China)

机构地区：[1]浙江中医药大学第一临床医学院,浙江省杭州310053 [2]绍兴市柯桥区中医医院呼吸内科,浙江省绍兴312030

出　　处：《中国基层医药》2018年第20期2635-2637,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省医学会临床科研项目（2015ZYC-A80）

摘　　要：目的 探讨中西医结合治疗慢性阻塞性肺疾病（COPD）伴呼吸肌疲劳的临床疗效及其对血清白细胞介素6（IL－6）、白细胞介素8（IL－8）的影响.方法 选取柯桥区中医医院2016年3月至2017年1月收治的COPD伴呼吸肌疲劳患者92例,采用随机数字表法分为观察组（ n＝46）和对照组（n＝46）,对照组采用西医常规治疗,观察组在对照组的基础上加用六君子汤治疗.观察两组治疗前后动脉血pH值、二氧化碳分压（PaCO2）、血氧分压（PaO2）等血气指标的变化以及血清IL－6、IL－8水平变化,比较两组临床疗效.结果 治疗前,两组动脉血pH、PaCO2、PaO2差异均无统计学意义（t＝0.274、0.108、0.233,均P＞0.05））;治疗后,观察组动脉血PaCO2为（37.18 ±3.06）mmHg,明显低于对照组的（40.23 ±2.97）mmHg（t＝7.004,P＜0.05）,观察组PaO2为（84.48 ±3.25）mmHg,明显高于对照组的（76.92 ±2.71）mmHg（t＝7.896,P＜0.05）,两组动脉血pH差异无统计学意义（t＝0.671,P＞0.05）.治疗前,两组血清IL－6、IL－8水平差异均无统计学意义（t＝0.506、0.412,均P＞0.05）;治疗后,观察组血清IL－6、IL－8水平分别为（14.27 ±1.05）pg/mL、（41.26 ±3.97）pg/mL,均明显低于对照组的（18.38 ±1.76）pg/mL、（60.54 ±4.31）pg/mL（t＝6.358、7.138,均P＜0.05）.观察组总有效率为97.8%,明显高于对照组的73.9%（χ2＝8.617,P＜0.05）.结论 采用中西医结合治疗COPD伴呼吸肌疲劳效果显著,可以有效缓解呼吸肌疲劳,改善患者血气指标,降低血清IL－6、IL－8水平,值得应用.Objective To investigate the clinical effect of integrated traditional Chinese and western medicine in the treatment of chronic obstructive pulmonary disease （ COPD） complicated with respiratory muscle fatigue ,and to analyze its effects on serum levels of interleukin-6（IL-6） and interleukin-8（IL-8）.Methods A total of 92 COPD patients complicated with respiratory muscle fatigue in the Traditional Chinese Medicine Hospital of Keqiao District were selected and randomly divided into observation group and control group according to the digital table ,with 46 cases in each group.The control group received routine treatment ,the observation group was given Liujunzi Decoction on the basis of the control group.The arterial blood pH values,blood carbon dioxide partial pressure（PaCO2）,partial pressure of oxygen（PaO2） and the changes of serum IL -6 and IL -8 levels were compared between the two groups .Results Before treatment,the arterial blood pH,PaCO2,PaO2between the two groups had no statistically significant differences（t=0.274,0.108,0.233,all P〉0.05）.After treatment,the arterial blood PaCO2of the observation group [（37.18 ± 3.06）mmHg] was significantly lower than that of the control group [（40.23 ±2.97）mmHg]（t=7.004,P〈0.05）. The PaO2of the observation group [（84.48 ±3.25） mmHg] was significantly higher than that of the control group [（76.92 ±2.71）mmHg]（t=7.896,P〈0.05）.There was no statistically significant difference between the two groups in arterial blood pH（t=0.671,P〉0.05）.Before treatment,the serum IL-6,IL-8 levels between the two groups had no statistically significant differences（t=0.506,0.412,all P〉0.05）.After treatment,the levels of serum IL-6,IL-8 in the observation group were （14.27 ±1.05）pg/mL,（41.26 ±3.97）pg/mL,respectively,which were significantly lower than those in the control group [（18.38 ±1.76）pg/mL,（60.54 ±4.31）pg/mL]（t=6.358,7.138,all P〈0.05）.The total effective rate of the observation group was 97.8%,wh

关 键 词：肺疾病  慢性阻塞性 呼吸肌 六君子汤 白细胞介素6 白细胞介素8 

分 类 号：R563.9[医药卫生—呼吸系统]