牡蛎壳羟基磷灰石多孔骨修复材料制备工艺研究  

Preparation technology of oyster hydroxyapatite porous material for bone repair

作　　者：薛启煌 邢永振 张其清[3] Xue Qihuang;Xing Yongzhen;Zhang Qiqing(FSP Jimin R＆D Center Co.,Ltd.,Fujian Bote Biotech Co.,Ltd.,Fuzhou 350000,Chin;Fujian GTR Biotech Co.,Ltd.,Fuzhou 350000,Chin;Institute of Biomedical Engineering,Chinese Academy of Medical Sciences ＆ Peking Union Medical College,Tianjin 300192,China)

机构地区：[1]福建南方济民医药研发中心有限公司,福建省博特生物科技有限公司,福州350000 [2]福建吉特瑞生物科技有限公司,福州350000 [3]中国医学科学院北京协和医学院生物医学工程研究所,天津300192

出　　处：《国际生物医学工程杂志》2018年第4期291-295,300,共6页International Journal of Biomedical Engineering

摘　　要：目的 验证水热反应法（220 ℃、6h）制备牡蛎壳羟基磷灰石（HA）的可行性,建立一种制备牡蛎壳HA多孔骨修复材料的方法,并实现对材料孔隙率和抗压强度的调控.方法 先采用水热反应法（220℃、6h）制备牡蛎壳HA,再以海绵浸渍和高温煅烧来获得HA多孔骨修复材料,并通过对浸浆次数和海绵吸附的浆料质量来调控材料的孔隙率和抗压强度.结果 220℃、6h的水热反应条件可使牡蛎壳CaC03有效转化为HA.浸浆次数为1、2、3次的正方体HA多孔骨修复材料（体积为1 cm^3）所吸收的浆料质量分别为0.184 8、0.318 1、0426 1 g,对应的材料孔隙率分别为91.5％、82.9％、78.5％,抗压强度分别为1.06、3.99、8.49 MPa.结论 牡蛎壳粉末在220℃、6h的水热反应条件下可有效转化为HA,采用海绵浸渍法制备HA多孔骨修复材料可得到理想的孔隙率和机械强度,但需通过调控海绵浸浆次数和吸收HA浆料的质量方可实现.Objective To verify the feasibility of applying hydrothermal synthesis for preparing oyster hydroxyapatite（HA） and to develop a preparation method of oyster HA porous material for bone repair.Methods Hydrothermal synthesis was applied for preparing oyster HA,and the reaction condition was 220 ℃ for 6 h.Then,the prepared oyster HA was used as the raw material for porous scaffold preparation by sponge-soaking and sintering,successively.The porosity and compressive strength of the scaffold were adjusted by controlling the soaking time and absorbed HA slurry of the sponges.Results Hydrothermal synthesis was an effective method for preparing oyster HA.When the volume of the sponge cube was 1 cm3,the material absorbed by one to three times sponge-soaking were 0.184 8 g,0.318 1 g and 0.426 1 g,respectively,the corresponding porosity were 91.5%,82.9% and 78.5%,and the compressive strength were 1.06 MPa,3.99 MPa and 8.49 MPa.Conclusion The oyster shell powder can be effectively converted into HA under the hydrothermal reaction condition of 220 ℃ for 6 h.The preparation of HA porous bone repair material by sponge-soaking method can obtain ideal porosity and mechanical strength.However,in this preparation process,the number of sponge-soaking and the weight of the absorbed HA slurry should be exactly controlled in order to obtain desired properties.

关 键 词：牡蛎壳 羟基磷灰石 骨修复材料 孔隙率 抗压强度 

分 类 号：R318.08[医药卫生—生物医学工程]