可携带人工肾的研究进展  

Research progress of portable artificial kidney

作　　者：解倩[1] 高庞业 郝文帅 张启蒙 Xie Qian;Gao Pangye;Hao Wenshuai;Zhang Qimeng(Nephrology Department,Peking University Third Hospital,Beijing 100191,China;Material Science and Engineering School,Yanshan University,Qinhuangdao 066004,Chin;Material Science and Engineering School,China University of Geosciences,Beijing 100083,China;Hemodialysis Room,Beijing Zhongguancun Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院肾内科,100191 [2]燕山大学材料科学与工程学院,秦皇岛066004 [3]中国地质大学(北京)材料科学与工程学院,北京100083 [4]北京中关村医院血液透析室,100191

出　　处：《国际生物医学工程杂志》2018年第4期342-347,共6页International Journal of Biomedical Engineering

摘　　要：慢性肾脏病严重影响着人类寿命和生活质量,其中终末期肾病（ESRD）患者接受透析治疗日益增多.由于方法的限制,传统透析极大地限制了患者的活动性,因此可携带人工肾的研发成为满足患者多元化需求的新方向.目前的可携带人工肾是分别基于血液透析和腹膜透析发展而来,包括可穿戴人工肾（WAK）和生物可植入式人工肾（BAK）.可携带人工肾在临床前实验已初步获得了成功,可基本满足治疗需求.其有望实现可移动的持续透析治疗模式,显著降低ESRD患者的住院率和死亡率,节省医疗资源,同时显著提高患者的生活质量,满足患者回归正常生活的需求.综述了WAK和BAK的研究现状,并对其未来发展作了展望.Chronic kidney diseases severely affects human health and quality of life.The end-stage renal disease （ESRD） patients require extensive blood purification treatments.Due to the limitations of methods,traditional dialysis treatments greatly limit the activity of the patients undergoing dialysis.Portable artificial kidneys can meet the diverse needs of these patients,and has become a new direction of research.There are two types of portable artificial kidneys,which are respectively based on hemodialysis and peritoneal dialysis,such as wearable artificial kidney （WAK） and bio-implantable artificial kidney （BAK）.At present,preclinical experiments with artificial kidneys have achieved initial success,basically meeting treatment needs.Portable artificial kidneys are expected to achieve a mobile continuous dialysis treatment,reduce hospitalization and mortality in ESRD patients,save medical resources,improve the life quality of the patients,and make the patients return to normal lifestyles.The research status of WAK and BAK was reviewed,and their future developments were prospected.

关 键 词：可携带人工肾 可穿戴人工肾 生物可植入式人工肾 终末期肾病 

分 类 号：R318.1[医药卫生—生物医学工程] R692.5[医药卫生—基础医学]