胰岛素腹腔给药的优势及可行性  

Advantages and feasibility of intraperitoneal insulin delivery

作　　者：夏婷 高关心 夏慧琳 张虹 杨涛 李岳飞 钟建 孙洪范[3] Xia Ting;Gao Guanxin;Xia Huilin;Zhang Hong;Yang Tao;Li Yuefei;Zhong Jian;Sun Honjan(Medical Engineering Department,hmer Mongolia People＇s Hospital,Inner Mongolia 010017,China;Shandong Yiersen Biatechnalogy Co.,Ltd.,Qingdao 266000,China;Institute of Biomedical Engineering,Chinese Academy of Medical Sciences ＆ Peking Union Medical College,Tianjin Key Laboratory of Biomedical Materials,Tianjin 300192,China)

机构地区：[1]内蒙古自治区人民医院医学工程处,010010 [2]山东宜尔森生物技术有限公司,青岛266000 [3]中国医学科学院北京协和医学院生物医学工程研究所,天津市生物医学材料重点实验室,天津300192

出　　处：《国际生物医学工程杂志》2018年第4期354-358,364,共6页International Journal of Biomedical Engineering

基　　金：内蒙古自治区科技计划资助项目（201702118）

摘　　要：在正常状态下,胰腺分泌的胰岛素首先经门静脉进入肝脏,形成肝脏高于外周循环的胰岛素浓度差.胰岛素皮下给药会形成外周胰岛素浓度高于肝脏的浓度差,这与正常生理条件不符,而胰岛素腹腔给药因更符合生理条件而得到广泛研究.综述了胰岛素腹腔给药的药代动力学和药效学研究结果.相对于皮下给药,胰岛素腹腔给药除了可减少低血糖发生率外,还具有不可忽视的纠正脂代谢异常的优势.这意味着腹腔给予胰岛素对于防治糖尿病并发症具有积极的作用,开发安全、低成本、操作简便的经皮腹腔给药装置是必要也是可行的.Under normal conditions,insulin secreted by the pancreas enters the liver through the portal vein,forming a difference in insulin concentration above the peripheral circulation.Subcutaneous administration of insulin forms a portal-peripheral concentration gradient of insulin above the liver,which is inconsistent with normal physiological conditions.Intraperitoneal insulin administration has been extensively investigated because that is closer to physiological state.In this paper,the pharmacokinetic and pharmacodynamic studies of insulin intraperitoneal administration were reviewed.Compared with the conventional subcutaneous delivery,intraperitoneal insulin administration can not only reduce the incidence of hypoglycemia,but also has the advantage of correcting abnormal lipid metabolism.This means that intraperitoneal administration of insulin has a positive effect on the prevention and treatment of diabetic complications.Therefore,it is necessary and feasible to develop a safe,low-cost,and easy-to-use percutaneous intraperitoneal insulin delivery device.

关 键 词：胰岛素 腹腔给药 脂代谢 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]