普萘洛尔和595nm脉冲染料激光治疗婴儿血管瘤的疗效  

Clinical efficacy of propranoiol and 595 nm pulsed dye laser in treatment of infantile hemangioma

作　　者：马志兵 金培生 张爱君 陶常波 李雪阳 沈才齐 郝英姿 丁伟伟 Ma Zhibing , Jin Peisheng , Zhang Aijun, Tao Changbo, Li Xueyang , Shen Caiqi, Hao Yingzi, Ding Weiwei(Department of Plastic Surgery, the Affiliated Hospital of Xuzhou Medical university, Xuzhou 221002, China)

机构地区：[1]徐州医科大学附属医院整形外科,221002

出　　处：《中华医学美学美容杂志》2018年第5期350-353,共4页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的探讨普萘洛尔和595nm脉冲染料激光治疗婴儿血管瘤的疗效。方法2013年1月至2015年1月，徐州医科大学附属医院整形外科收治26例婴儿血管瘤，均口服普萘洛尔2mg／（kg·d），每日8：00和20：OO分2次服药，持续心电监护及指脉氧监测。每2周复查血常规、空腹血糖和肝肾功能，记录瘤体颜色大小等变化并拍照存档。终止服药时未痊愈婴儿行595nm脉冲染料激光治疗，随访6～12个月。结果普萘洛尔治疗72h，瘤体张力和颜色均有不同程度减轻，终止用药时痊愈19例，显效3例，有效4例，未痊愈7例经595nm脉冲染料激光治疗3～5次痊愈。全部治愈。主要不良反应为轻度可逆性心率变缓10例，未行任何处理。腹泻5例，经对症治疗缓解。结论普萘洛尔和595nm脉冲染料激光治疗婴儿血管瘤疗效显著。Objective To observe the clinical efficacy of propranolol and 595 nm pulsed dye laser （PDL） in treatment of infantile hemangioma. Methods 26 infants admitted to our hospital from January 2013 to January 2015 with hemangioma underwent oral propranolol 2 mg/（kg · d） treatment after excluding of taboos. The daily doses were divided equally to two parts, taken on the time of 8：00 and 20：00, when the electrocardiograph and pulse oxygen were monitored and recorded persistently. The patients were discharged from the hospital when it was stable, with review of blood routine exam- ination, fasting blood glucose, liver and kidney function, and the change of size, character and color of hemangioma were recorded, and taken photos every two weeks after discharge. The 595 nm PDL was used to treat the hemangioma faded incompletely when the propranolol was terminated. Results The tension and color of all hemangioma decreased in varying degrees in taking propranolol for 72 hours, and evaluated the efficacy as recovery completely 19 cases; signifivantly effective in 3 cases and partial efficacy in 4 cases; the latter 7 cases were further treated with 595 nm PDL. Followed-up for 6-12 months showed that efficacy of recovery reached 100%. 10 cases showed heart rate was mild reversibly slow, with no special treatment. 5 cases had diarrhea, and healed with symptomatic treatment. No adverse reactions like liver and kidney dysfunction and so on were found. Conclusions Propranolol and 595 nm PDL can effectively treat infantile hemangioma, and thus it can be used as the recommended treatment of infantile hemangioma.

关 键 词：血管瘤 普萘洛尔 激光器 染料 婴儿 治疗结果 

分 类 号：R732.2[医药卫生—肿瘤]