皮秒翠绿宝石激光治疗太田痣的疗效和安全性  

Efficacy and safety of picosecond Alexandrite laser in treatment of nevus of Ota

作　　者：贾高蓉 房静 林彤 杨寅 Jia Gaorong, Fang Jing, Lin Tong, Yang Yin(Institute of Dermatology and Hospital for Skin Diseases, Chinese Academy of Medical Sciences （CAMS）, Nanjing 210042, China)

机构地区：[1]中国医学科学院北京协和医学院皮肤病医院激光科,南京210042

出　　处：《中华医学美学美容杂志》2018年第5期357-360,共4页Chinese Journal of Medical Aesthetics and Cosmetology

基　　金：中国医学科学院医学与健康科技创新工程重大协同创新项目（CIFMS-2017-12M-1-017）;江苏省重点研发计划（社会发展）面上项目（BE2017808）

摘　　要：目的分析皮秒翠绿宝石激光治疗太田痣的疗效、安全性和影响因素。方法2015年10月至2017年10月，中国医学科学院皮肤病医院激光科对49例太田痣患者进行皮秒翠绿宝石激光治疗，并根据患者性别、发病年龄、治疗1次年龄、皮损Tanino分型和颜色分级进行分组，对临床特征、治疗效果、不良反应、疗效影响因素等进行分析。结果49例太田痣患者接受1～4次治疗，痊愈9例，其中治疗1次痊愈3例。治疗1次显效率达28．6％，有效率达53．1％，8例治疗3次全部有效，5例治疗4次全部显效。不同性别、发病年龄、Tanino分型、颜色分级各组之间的治疗1次疗效比较，差异无统计学意义（P〉0．05）。治疗1次年龄与疗效差异有统计学意义（P〈0．05），年龄与疗效呈反比关系，年龄越小，效果越好。2例患者治疗后出现色素沉着，6个月后消退，无明显瘢痕、色素减退等不良反应出现。结论皮秒翠绿宝石激光治疗太田痣疗效好，安全性高。Objective To analyze the efficacy, safety and the correlative influencing factors of picosecond Alexandrite laser in the treatment of nevus of Ota. Methods 49 patients with nevus of Ota receiving picosecond Alexandrite laser in our department from October 2015 to October 2017 were retrospectively analyzed, and grouped according to patient gender, age of onset, age of first treatment, Tanino classification of skin lesions and color grading. Clinical characteristics, treatment effects, adverse reactions, influencing factors and other factors were analyzed. Results 49 patients with nevus of Ota were treated 1-4 times, and 9 cases were cured. After one treatment, the significant effective rate was 28.6 %, the effective rate was 53.1%, and the effective rate was 100 % after 3 treatments, and the effective rate was 100% after 4 treatments. No significant difference was found in the first treatment efficacy between different genders, age of onset, Tanino classification and color grading （P〉0.05）. There was a significant difference in the first treatment effect between different first treatment age groups （P〈0.05）. The inverse relationship between age and efficacy was found. The youn- ger the age, the better the first treatment effect. Pigmentation appeared in 2 patients after treatment and subsided after 6 months. No adverse reactions such as scars and hypopigmentation appeared. Conclusions Picosecond Alexandrite laser is a safe and highly effective therapy for nevus of Ota.

关 键 词：太田痣 激光 有效性 安全性 皮秒翠绿宝石激光 

分 类 号：R758.51[医药卫生—皮肤病学与性病学]