^(131)I-chTNT单克隆抗体放射免疫治疗14例晚期胰腺癌的护理  

Nursing experience of ^(131)I-chTNT radioimmunotherapy of 14 patients with advanced pancreatic cancer

作　　者：潘敏敏 俞丽敏[1] 陆影[1] PAN Minmin;YU Limin;LU Ying(Department of Interventional Therapy,Tongji Hospital Affiliated to Tongji University,Shanghai 200065,China)

机构地区：[1]同济大学附属同济医院介入科,上海200065

出　　处：《外科研究与新技术》2018年第3期218-220,共3页Surgical Research and New Technique

摘　　要：目的通过对14例晚期胰腺癌患者瘤体内注射^(131)I-chTNT(^(131)I标记的肿瘤细胞核单克隆抗体)治疗胰腺癌的护理观察,总结^(131)I-chTNT单克隆抗体放射免疫治疗胰腺癌的护理要点。方法所有胰腺癌患者(n=14)均采用计算机断层扫面引导下瘤体内直接注射^(131)I-chTNT注射液(50 mCi),并给于全面细致的护理,包括术前健康教育及术后并发症护理与观察。结果 14例患者在科学、系统、精心的治疗护理下,手术全部顺利完成,成功率100%,随访完全缓解(CR) 1例(7%),部分缓解(PR) 4例(29%),稳定(SD) 7例(50%),进展(PD) 2例(14%),有效率CR+PR 36%,未发生严重并发症。结论足够的剂量^(131)I-chTNT单克隆抗体瘤体内注射对于晚期胰腺癌的治疗效果显著,是一种安全有效的新方法,围手术期加强心理护理,生命指征监测,并发症的预防及护理,是确保手术成功及防止相关并发症的有力保障。Objective To summarize the nursing key points of radioimmunotherapy of pancreatic cancer by observing the nursing care in 14 patients with advanced pancreatic cancer receiving injection of 131I-chTNT （iodine-131- lablbed tumor necrosis therapy chimeric antibody）. Methods All pancreatic cancer patients （n = 14） were treated with computed tomography （CT） guided 131I-chTNT intratumoral injection, and received comprehensive nursing including preoperative health education and postoperative complication nursing care. Results All patients were successfully treated with 131 I-chTNT intratumoral injection with scientific, systematic, and meticulous nursing. The success rate was 100%. Specifically, 1 case had a complete response （CR） （7%）, 4 cases achieved partial response （PR） （29%）, 7 cases had stable conditions （50%）, and 4 cases progressed （14%）. The effective rate was 36%. Conclusions These promising results demonstrate that sufficient doses of 131 I-chTNT can be safely delivered to tumors to cause significant therapeutic effects on advanced pancreatic cancer. Perioperative psychological nursing, monitoring of vital signs, prevention and nursing of complications are a powerful guarantee for successful operation and prevention of complications.

关 键 词：^131I-chTNT标记的肿瘤细胞核单克隆抗体 胰腺癌 放射免疫治疗 护理 

分 类 号：R473[医药卫生—护理学]