超滤法测定盐酸麻黄碱的血浆蛋白结合率  

Plasma Protein Binding Rate of Ephedrine Hydrochloride by Ultrafiltration

作　　者：鲍慧玮 徐阳 刘芳馨[1] BAO Hui-wei;XU Yang;LIU Fang-xin(Changehun University of Chinese Medicine,Changehun Jilin 130117,China;Changehun Medical College,Changehun Jilin 130000,China)

机构地区：[1]长春中医药大学,吉林长春130117 [2]长春医学高等专科学校,吉林长春130000

出　　处：《长春师范大学学报》2018年第10期78-81,共4页Journal of Changchun Normal University

摘　　要：本文采用超滤法结合HPLC法测定盐酸麻黄碱与小鼠、大鼠、家兔的血浆蛋白结合情况。结果表明,盐酸麻黄碱与小鼠、大鼠、家兔的平均血浆蛋白结合率分别为(35. 60±0. 56)%、(36. 21±0. 52)%、(37. 71±0. 54)%。盐酸麻黄碱与小鼠、大鼠、家兔血浆均具有较弱的结合,无浓度依赖性,但有差异性。The plasma protein binding of ephedrine hydrochloride to mice,rats and rabbits was determined by ultrafiltration and HPLC.The results showed that the average plasma protein binding rates of ephedrine hydrochloride to mice,rats and rabbits were（ 35. 60 ±0. 56） %,（ 36. 21 ± 0. 52） % and（ 37. 71 ± 0. 54） %,respectively. Ephedrine hydrochloride had weak binding with plasma protein of mice,rats and rabbits,and had no concentration dependence.

关 键 词：盐酸麻黄碱 超滤法 HPLC法 血浆蛋白结合率 

分 类 号：R284.1[医药卫生—中药学]