血清纤溶酶原激活物抑制物-1水平与2型糖尿病合并超重或肥胖病人的血管并发症的相关性研究  

RESEARCHING THE CORRELATION OF VASCULAR COMPLICATIONS OF THE ORIGINAL SERUM FIBRINOLYTIC ENZYME ACTIVATORS INHIBITOR 1 LEVEL AND THE OBESITY PATIENTS WITH TYPE 2 DIABETES

作　　者：薛君[1] 张雅楠 蔡志杰[1] 董智慧[1] 石丹华 曹晓晶[1] 王颖[1] 贾吉祥 XUE Jun;ZHANG Ya-nan;CAI Zhi-jie(The Third Affiliated Hospital of Inner Mongolia Medical University,Baotou 014010 China)

机构地区：[1]内蒙古医科大学第三附属医院老年病科,内蒙古包头014010

出　　处：《内蒙古医科大学学报》2019年第1期42-46,共5页Journal of Inner Mongolia Medical University

基　　金：包头市医药卫生科技计划项目(wsjj2016089)

摘　　要：目的:通过观察2型糖尿病(T2 DM)合并超重或肥胖病人血清纤溶酶原激活物抑制物-1(PAI-1)水平变化,同时观察糖脂代谢相关指标、脂肪细胞分泌的炎症因子的变化,并与PAI-1作相关分析,探讨2型糖尿病合并超重或肥胖病人PAI-1水平的变化。方法:选取健康体检者36例作为正常对照组(NC组),将实验组分为2型糖尿病组(T2 DM组) 54例,超重或肥胖组35例,2型糖尿病合并超重或肥胖组(T2 DM+肥胖组) 48例,观察并比较各组间糖脂代谢相关指标,空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、胰岛素抵抗指数(IR)、体重指数(BMI),及炎症相关因子,白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及PAI-1水平,并与PAI-1做相关分析。结果:(1)与NC组比较,T2 DM组FBG、HbA1c、FINS、IR升高,差异有统计学意义,TG、TC、LDL、BMI差异无统计学意义;超重或肥胖组FINS、IR、TG、LDL、TC、BMI升高,差异有统计学意义,FBG、HbA1c差异无统计学意义; T2 DM+超重或肥胖组FBG、HbA1c、FINS、IR、TG、LDL、TC、BMI升高,差异有统计学意义。与T2 DM组比较,超重或肥胖组TG、TC、LDL、BMI升高,差异有统计学意义,FBG、HbA1c、FINS、IR降低,差异有统计学意义; T2 DM+超重或肥胖组FINS、IR、TG、TC、LDL、BMI升高,差异有统计学意义,FBG、HbA1c、差异无统计学意义。与超重或肥胖组比较,T2 DM+超重或肥胖组FBG、FINS、IR、HbA1c、LDL升高,差异有统计学意义,TG、TC、BMI差异无统计学意义。(2)与NC组比较,T2 DM组、超重或肥胖组及T2 DM+超重或肥胖组IL-6、TNF-α、PAI-1升高,差异有统计学意义。与T2 DM组比较,超重或肥胖组IL-6、TNF-α升高,差异有统计学意义,PAI-1差异无统计学意义; T2 DM+超重或肥胖组IL-6、TNF-α、PAI-1升高,差异有统计学意义。与超重或肥胖组比较,T2 DM+超重或肥胖组IL-6、TNF-α差异无统计学意义;Objective： By observing the PAI - 1 level change of the patients with T2 DM and overweight or obesity, at the same time observing the glucolipid metabolism related indicators, the change of the inflammation factors secreted by the fat cells , and makeing correlation analysis, reserch the relationship betwen the level of PAI - 1 and type 2 diabetes with overweight or obesity. Methods： Choose healthy check-up 36 cases as normal control group （NC group）, dividing into the experimental group of type 2 diabetes （T2 DM） group 54 cases of type 2 diabetes mellitus and overweight or obesity group （T2 DM ＋ obese） 48 cases and to observe and compare the glucolipid metabolism related index（ fasting blood glucose FBG, triglyceride TG, total cholesterol TC , low density lipoprotein cholesterol LDL, glycated hemoglobin HbA 1 c, fasting insulin FSI, insulin resistance indexIR, body weight index BMI） between groups , inflammation related factor （interleukin - 6 IL - 6, tumor necrosis factor TNF-α） and PAI-1 level,and make correlation analysis with PAI-1. Results： （1）Compared with NC group, T2 DM group FBG、HbA 1 c、FINS、 IR、 IL-6、TNF-α、PAI -1 were elevated, and the differences were statistically significant （all P 〈 0.05 ）, and there was no statistically significant difference between TG、 TC、LDL and BMI. T2 DM ＋ overweight or obesity group FBG、 HbA 1 c、 FINS、 IR、TG、LDL、BMI、IL-6、TNF-α、PAI - 1 were elevated, and the differences were statistically significant （all P 〈 0.05 ）, and the TC difference was not statistically significant. （2）Compared with T2 DM group, T2 DM ＋ overweight or obesity group FINS、 IR、TG、LDL、BMI、IL-6、TNF-α、PAI - 1 were elevated, and the differences were statistically significant （all P 〈 0.05 ）, and there was no statistically significant difference between FBG、HbA 1 c and TC. Multifactor Logistic regression analysis showed positive correlation between HbA 1 c、IR、TG、BMI、IL-6、TNF-α and PAI - 1 �

关 键 词：血浆纤溶酶原激活物抑制物-1 2型糖尿病 超重或肥胖 

分 类 号：R587.1[医药卫生—内分泌]