Incremental age-related one-year MACCE after acute myocardial infarction in the drug-eluting stent era （from KAMIR-NIH registry）  

作　　者：Dae-Won Kim Sung-Ho Her Ha Wook Park Kiyuk Chang Wook Sung Chung Ki Bae Seung Myung Ho Jeong Hyo-Soo Kim Hyeon Cheoi Gwon In Whan Seong Kyung Kuk Hwang Shung Chull Chae Kwon-Bae Kim Young Jo Kim Kwang Soo Cha Seok Kyu Oh Jei Keon Chae Ji-Hoon Jung 

机构地区：[1]Division of Cardiology, Daejeon St. Mary's Hospital, College of Medicine, the Catholic University of Korea, Seoul, South Korea [2]Division of Cardiology, Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea, Seoul, South Korea [3]Chonnam National University Hospital, Gwangju, South Korea [4]Seoul National University Hospital, Seoul, South Korea [5]Sungkyunkwan Universtiy Samsung Medical Center, Seoul, South Korea [6]Chungnam National University Hospital, Daejeon, South Korea [7]Chungbuk National University Hospital, Cheongju, South Korea [8]Kyungpook National University Hospital, Daegu, South Korea [9]Keimyung University Dongsan Medical Center, Daegu, South Korea [10]Yeungnam University Hospital, Daegu, South Korea [11]Pusan National University Hospital, Busan, South Korea [12]Wonkwang University Hospital Iksan, South Korea [13]Chonbuk National University Hospital, Jeonju, South Korea [14]Statistical Manager, Institute of Toxicology, Daejeon, South Korea

出　　处：《Journal of Geriatric Cardiology》2018年第9期574-584,共11页老年心脏病学杂志（英文版）

摘　　要：Objectives To evaluate the age-related one-year major adverse cardiocerebrovascular events （MACCE） after percutaneous coronary intervention （PCI） in acute myocardial infarction （AMI）. We analyzed the association between age and one-year MACCE after AMI. Methods A total of 13,104 AMI patients from Korea Acute Myocardial Infarction Registry-National Institue of Health （KAMIR-NIH） between November 2011 and December 2015 were classified into four groups according to age （Group I, 〈 60 years, n = 4199; Group II, 60-70 years, n = 2577; Group III; 70-80 years, n = 2774; Group IV, ≥ 80 years, n = 1018）. Patients were analyzed for one-year composite of MACCE （cardiac death, myocardial infarction, target vessel revascularization, cerebrovascular events） after AMI. Results The one-year MACCE in AMI were 3.5% （Group I）, 6.3% （Group II）, 9.6% （Group III） and 17.6% （Group IV）. After adjustment for confounding para- meters, the analysis results showed that patients with AMI had incremental risk of one-year MACCE [Group II, adjusted hazard ratios （aHR） = 1.224, 95% CI： 0.965-1.525, P = 0.096; Group III, aHR = 1.316, 95% CI： 1.037-1.671, P= 0.024; Group IV, aHR = 1.975, 95% CI： 1.500-62.601, P〈 0.001） compared to Group I. Especially, cardiac death in the composite of primary end point played a major role in this effect （Group II, aHR = 1.335, 95% CI： 0.941-1.895, P= 0.106; Group III, aHR = 1.575, 95% CI： 1.122-2.210, P= 0.009; Group IV, aHR = 2.803, 95% CI： 1.937-4.054, P 〈 0.001）. Conclusions Despite advanced techniques and medications for PCI in AMI, age still exerts a powerful influence in clinical outcomes. Careful approaches, even in the modem era of developed cardiology are needed for aged-population in AMI intervention.

关 键 词：Acute myocardial infarction Aged-population Major adverse cardiocerebrovascular events 

分 类 号：Q141[生物学—生态学] Q95-33[生物学—普通生物学]