长链非编码RNA TERRA的研究进展  

The Research Advance of Long Non-coding RNA TERRA

作　　者：范源 罗嘉 甘麦邻 谭娅 张顺华 朱砺 FAN Yuan;LUO Jia;GAN Mai-lin;TAN Ya;ZHANG Shun-hua;ZHU Li(College of Animal Science and Technology,Sichuan Agricultural University,Chengdu 611130,China;Institute of Animal Husbandry and Veterinary,Guizhou Academy of Agricultural Science,Guiyang 550005,China)

机构地区：[1]四川农业大学动物科技学院,成都611130 [2]贵州省农业科学院畜牧兽医研究所,贵阳550005

出　　处：《中国生物工程杂志》2018年第10期171-180,共10页China Biotechnology

基　　金：四川省科技支撑计划(16ZC2838,2017NFP0135,2016NZ0089)资助项目

摘　　要：端粒是染色体末端的特殊结构,对染色体具有保护作用,并且和衰老及很多疾病相关。长链非编码RNA是长度大于200bp且一般不具有编码功能的RNA。TERRA（telomeric repeat-containing RNA）是由端粒重复序列转录的一类长链非编码RNA,研究表明TERRA具有参与调控端粒长度,促进异染色体形成和保护染色体末端等功能,并且TERRA的表达与疾病和衰老相关。由于TERRA对于端粒具有重要作用,因此对于TERRA的研究已经成为端粒相关研究中的热点。目前对于TERRA的转录调控及生物学功能已有较为深入的了解。现对TERRA的生物学特性,功能和与疾病及衰老的关系进行综述,以期为TERRA后续的研究如作为疾病治疗靶点,延缓衰老等提供参考。Telomeres are specialized structures at the ends of the chromosomes,which have protective effects on the ends of chromosomes,and are associated with aging and many diseases. Long non-coding RNAs are RNAs that are greater than 200 bp in length and generally do not produce a protein product. TERRA（ telomeric repeat-containing RNA） is a type of long non-coding RNA that transcribed from telomere repeats. Emerging studies have shown that TERRA has functions of regulating telomere length, promoting the formation of heterochromosomes,also protecting the ends of chromosomes,and the expression levels of TERRA are related to diseases and aging. Since TERRA plays an important role in telomeres,the studies of TERRA has become a spotlight in researches related to telomere. At present,the transcriptional regulation and biological functions of TERRA have been well studied. Reviewing the biological characteristics and functions of TERRA and its relationship with disease and aging provides reference for the subsequent study of TERRA,which may be act as a target for the treatment of disease treatment and aging.

关 键 词：TERRA 端粒 端粒长度 染色体末端 长链非编码RNA 

分 类 号：Q522[生物学—生物化学]