光果甘草根中黄酮类化学成分研究  

Chemical constituents of flavonoids from roots of Glycyrrhiza glabra

作　　者：杜琳 常波 张琦 杨帆 杜伟[2] DU Lin;CHANG Bo;ZHANG Qi;YANG Fan;DU Wei(College of Chemistry and Life Science,Chengdu Normal University,Chengdu 611130,China;Department of Neurosurgery,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]成都师范学院化学与生命科学学院,四川成都611130 [2]郑州大学第一附属医院神经外科,河南郑州450052

出　　处：《中草药》2018年第20期4780-4784,共5页Chinese Traditional and Herbal Drugs

基　　金：四川省科技厅应用基础研究(面上)项目(2017JY0192)

摘　　要：目的研究光果甘草Glycyrrhiza glabra根中的化学成分。方法利用硅胶柱色谱及半制备HPLC进行分离纯化,通过理化性质及现代波谱技术对分离得到的化合物进行结构鉴定。结果从光果甘草醋酸乙酯部位分离得到10个异黄烷类化合物,分别鉴定为光甘草素T(1)、光甘草定(2)、glyasperin C(3)、甘草西定(4)、异甘草黄酮醇(5)、甘草异黄酮A(6)、甘草异黄酮B(7)、半甘草异黄酮B(8)、芒柄花素(9)、甘草素(10)。结论化合物1为新的异黄烷类化合物,化合物3～6为首次从该植物中分离得到。Objective To study the chemical constituents from the roots of Glycyrrhiza glabra.Methods Compounds were separated and purified by silica gel and preparative HPLC.The structures were identified by physicochemical properties and spectral analyses.Results Ten isoflavanes were isolated and identified as glabrene T（1）,glabridin（2）,glyasperin C（3）,licoricidin（4）,isolicoflavonol（5）,licoisoflavone A（6）,licoisoflavone B（7）,semilicoisoflavone B（8）,formononetin（9）,and liquiritigenin（10）,respectively.Conclusion Compound 1 is a new isoflavane.Compounds 3—6 are isolated from this plant for the first time.

关 键 词：光果甘草 异黄烷 光甘草素T 甘草西定 异甘草黄酮醇 甘草异黄酮A 

分 类 号：R284.1[医药卫生—中药学]