痛泻要方干预肝郁脾虚型溃疡性结肠炎机制探讨  

The mechanism of Tong Xie Yao Fang to intervene the ulcerative colitis of liver Qi stagnation and spleen deficiency

作　　者：蒋志滨 高洁[2] 李文[2] 柴艺汇 管连城 陈云志[2] JIANG zhi-bin;GAO Jie;LI Wen;CHAI Yi-hui;GUAN Lian-cheng;CHEN Yun-zhi(Pharmacy College,Guiyang University of Chinese Medicine,Guiyang 550025,China;Basic Medicine School,Guiyang University of Chinese Medicine,Guiyang 550025,China;Experiment Center,Guiyang Uni-versity of Chinese Medicine,Guiyang 550025,China)

机构地区：[1]贵阳中医学院药学院,贵州贵阳550025 [2]贵阳中医学院基础医学院,贵州贵阳550025 [3]贵阳中医学院实验中心,贵州贵阳550025

出　　处：《时珍国医国药》2018年第9期2121-2123,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(81760827);贵州省科技计划项目(黔科合基础[2017]1401);贵州省教育厅创新群体重大研究项目(黔教合KY字[2017]041);贵州省普通高等学校治未病工程中心(黔科合KY[2016]013);贵阳中医学院博士启动基金

摘　　要：溃疡性结肠炎(Ulcerative colitis,UC)是一种原因不明的慢性非特异性炎症性肠道疾病,被世界卫生组织列为当代难治性疾病之一。5-HT信号系统异常可导致胃肠动力、分泌功能紊乱,与UC病情严重程度、组织损伤呈正相关。肝脏SCD1表达下调会加剧UC的发展,与SCD1调节饱和脂肪酸与不饱和脂肪酸的动态平衡密切相关。5-HT可能作用于肝脏5-HT2受体,调节SCD1的表达。相关研究认为UC缓解期以肝脾不和为基本证候,5-HT与肝脏SCD1表达在UC发病中具有相互的关联性,由此推测痛泻要方治疗肝郁脾虚型UC可能通过调节肝脏SCD1与肠道5-HT平衡实现。Ulcerative colitis,as one of modern refractory diseases by the World Health Organization,is a chronic unspecified inflammatory bowel disease with unknown causes.5-HT signal system abnormalities can lead to gastrointestinal motility,secretion dysfunction,and is positively correlated with severity of illness,histological damage.SCD1 down-regulation could exacerbate the development of UC,due to a dynamic balance in SCD1 regulating saturated fatty acids and unsaturated fatty acids.It is presumed be associated with 5-HT and SCD1 expression in ulcerative colitis based on that 5-HT regulate expression of SCD1 by5-HT2 receptors in the liver.Thus,it is hypothesized by our research group that Tong Xie Yao Fang regulated UC patients with syndrome of liver Qi stagnation and spleen deficiency via balancing liver SCD1 and intestinal 5-HT.

关 键 词：痛泻要方 肝郁脾虚证 溃疡性结肠炎 硬脂酰辅酶A去饱和酶1 5羟色胺 

分 类 号：R285.5[医药卫生—中药学]