细胞因子在巴贝虫感染中的作用研究进展  

Advances in the study of the role of cytokines in babesiosis

作　　者：沈慧敏 蔡玉春[2] 郑葵阳 陈家旭[2] SHEN Hui-min;CAI Yu-chun;ZHENG Kui-yang;CHEN Jia-xu(Xuzhou Medical University,Xuzhou 221004,Jiangsu,China;National Institute of Parasitic Diseases,Chinese Center for Disease Control and Prevention,Key Laboratory of Parasite and Vector Biology,Ministry of Health,National Center for Research on Tropical Diseases,WHO Collaborating Center for Tropical Diseases,Shanghai 200025)

机构地区：[1]徐州医科大学,江苏徐州221004 [2]中国疾病预防控制中心寄生虫病预防控制所、国家热带病研究中心、卫生部寄生虫与媒介生物重点实验室、世界卫生组织热带病合作中心

出　　处：《中国病原生物学杂志》2018年第10期1175-1176,F0003,F0004,共4页Journal of Pathogen Biology

基　　金：国家重点研发计划项目(No.2016YFC1202000,2016YFC1202700);公益性卫生行业科研专项(No.201202019)

摘　　要：巴贝虫感染伴随着复杂的免疫应答过程,细胞因子在巴贝虫感染过程中发挥着很重要的作用,与巴贝虫感染的发生、发展、预后有着密不可分的关系。本文主要从功能方面具体阐述TNF-α、IFN-γ以及白细胞介素等细胞因子在巴贝虫感染中发挥的作用。Babesiosis is a tick-borne disease caused by the intraerythrocytic protozoan parasite Babesia. This disease is characterized by a host complex immune response that involves both cellular and humoral immunity. Cytokines play an important role in the process of Babesia infection and are closely related to the development and progression of babesiosis and its prognosis. Proinflammatory cytokines, such as TNF-α, IFN-γ, IL-2, and IL-12, are needed to initiate an effective inflammatory response and promote the elimination of Babesia parasites. In contrast, the cytokines IL-4 and IL-10 inhibit the cell-mediated inflammatory response by down-regulating the synthesis of pro-inflammatory cytokines. This article specifically describes, in terms of function, how TNF-α, IFN-γ, interleukins, and other cytokines play an important role in the development of babesiosis.

关 键 词：巴贝虫感染 免疫应答 细胞因子 综述 

分 类 号：R382[医药卫生—医学寄生虫学]