伊曲康唑的免疫调节作用及其临床应用——重新认识伊曲康唑  

The Immunoregulation Function and Clinical Application of Itraconazole—— A New Understanding of Itraconazole

作　　者：梁官钊[1] 郑晓丽[2] 刘维达[1] LIANG Guanzhao;ZHENG Xiaoli;LIU Weida(Department of Mycology,Institute of Dermatology,Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing 210042,China;Department of Dermatology,the Affiliated Hospital of Qingdao University,Qingdao 266003,China)

机构地区：[1]中国医学科学院&北京协和医学院皮肤病研究所真菌科,江苏南京210042 [2]青岛大学附属医院皮肤科,山东青岛266003

出　　处：《中国皮肤性病学杂志》2018年第11期1336-1340,共5页The Chinese Journal of Dermatovenereology

基　　金：中国医学科学院医学与健康创新工程项目资助(2016-12M-3-021)

摘　　要：近年,伊曲康唑的非抗真菌作用正被人们不断认识。此前,笔者已经总结了伊曲康唑的抗肿瘤作用,拓宽了人们对伊曲康唑的认识。研究发现,伊曲康唑对掌跖脓疱病、扁平苔藓、脂溢性皮炎、特应性皮炎、接触性皮炎等存在治疗作用,提示其存在潜在免疫调节作用。在此,笔者对伊曲康唑免疫调节作用进行综述,以期再次拓宽伊曲康唑的临床应用范围。More Functions of itraconazolewere found beyond its antifungal effects, for instance, lately we summarized its anti-tumor effects, which brought new understanding towards itraconazole. Further, researchers have found therapeutic effects of itraconazole on pustulosispalmoplantaris, lichen planus, sebon＇heic dermatitis, atopic dermatitis, contact dermatitis, ect,which indicated its potential immunoregulatory effects. In this paper, we reviewed the immunoregulatory effects of itraconazolehoping to expand itsclinical applicationsagain.

关 键 词：伊曲康唑 免疫调节 掌跖脓疱病 扁平苔藓 脂溢性皮炎 特应性皮炎 

分 类 号：R961[医药卫生—药理学]