2015-2017年泰州市疑似预防接种异常反应监测数据分析  

Surveillance of adverse events following immunization in Taizhou,2015-2017

作　　者：唐万琴[1] 朱中奎[1] 解燕[1] 王超[1] 肖辉 TANG Wan - qin, ZHU Zhong - kui, XIE Yan, WANG Chao, XIAO Hui(Department of Immunization Program, Taizhou Center for Disease Control and Prevention, Taizhou, Jiangsu 225300, China)

机构地区：[1]泰州市疾病预防控制中心免疫规划科,江苏泰州225300

出　　处：《现代预防医学》2018年第21期4008-4012,共5页Modern Preventive Medicine

摘　　要：目的描述2015-2017年泰州市疑似预防接种异常反应监测结果。方法收集2015-2017年发生AEFI个案资料和疫苗接种数据,采用描述性方法和多重对应分析进行流行病学研究。结果 2015-2017年泰州市共计报告AEFI病例2 282例,AEFI发生率71. 11/10万剂,其中一般反应2 082例,占91. 23%;异常反应196例,占8. 59%;偶合症4例,占0. 18%;男女性别比为1. 31∶1; 6-8月报告数最多; 93. 78%的AEFI发生在24 h内;报告数位居前3位的疫苗为百白破疫苗、A群流脑疫苗、麻风疫苗;麻风疫苗与异常反应关联性较强。结论泰州市AEFI监测系统敏感性逐年提高,疫苗安全性较好,需要进一步加强加强AEFI主动监测工作。Objective To analyze the features of adverse events following immunization （AEFI） in Taizhou from 2015 to 2017. Methods Data of AEFI eases and vaccinations were collected from 2015 to 2017 based on AEFI information management and vaccination system. Descriptive statistical method and MCA were used to analyze the data. Results A total of 2282 cases of AEFI were reported in Taizhou City from 2015 to 2017, with a reported incidence of 71.11/100000. 2082 （91.23%） had common reaction, 196 （8.59%） had rare reaction, and 4 （0.18%） had coincidental events. The ratio of male -to -female was 1.31 ： 1. Cases often occurred from June to August. The reactions concentrated within 24 hours after vaccination, accounting for 93.78%. The first three proportions of AEFI were related to vaccinations of Diphtheria, tetanus and acellular pertussis combined vaccine （ DTaP）, Group A meningococcal polysaccharide vaccine （ MPV - A）, and Measles and rubella Combined attenuated live vaccine （MR）. MR was closely related with rare reaction. Conclusion The sensitivity of AEFI monitoring increases in Taizhou City year by year, and the quality of vaccination service is satisfactory. It is necessary to further strengthen AEFI monitoring.

关 键 词：疑似预防接种异常反应 多重对应分析 疫苗 

分 类 号：R186[医药卫生—流行病学]