解毒三根汤痰毒同治抗消化道肿瘤作用初探  

Analysis of Jiedu Sangen Decoction on anti-gastrointestinal tumor effect by treating phlegmatic and toxin with same method

作　　者：刘磊[1] 张光霁[1] 徐楚韵 张广顺[1] LIU Lei;ZHANG Guang-ji;XU Chu-yun;ZHANG Guang-shun(Zhejiang Chinese Medical University,Hangzhou 310053,China)

机构地区：[1]浙江中医药大学,杭州310053

出　　处：《中华中医药杂志》2018年第11期4824-4826,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81273904)~~

摘　　要：在中国,癌症已成为疾病死因之首,4种最常见肿瘤分别为肺癌、胃癌、肝癌和食管癌,其中消化道肿瘤占了一半。饮食失宜是引发消化道肿瘤的关键病因,痰毒互结是消化道肿瘤发生发展的基本病机,清热解毒、祛湿化痰是治疗消化道肿瘤的基本治法。解毒三根汤痰毒同治抗肿瘤的作用机制主要是调控肿瘤相关成纤维细胞抑制肿瘤细胞迁移侵袭,抑制肿瘤细胞增殖;其抑制肿瘤血管生成、调节免疫等作用机制需要今后进一步研究。In China, cancer has become the leading cause of death. The four most common tumors are lung cancer, stomach cancer, liver cancer and esophageal cancer, of which gastrointestinal tumors account for a half. Improper diet is the key cause of gastrointestinal tumors. Intermingled phlegm and toxin is the basic pathogenesis of the development of gastrointestinal tumors. Clearing heat and removing toxicity and eliminating dampness and resolving phlegm are the basic treatment for gastrointestinal cancer. The mechanism of anti-tumor effect of Jiedu Sangen Decoction is mainly to regulate tumor-associated fibroblasts to inhibit tumor cell migration and invasion and inhibit tumor cell proliferation; its mechanism of inhibiting tumor angiogenesis and regulating immunity needs further study in the future.

关 键 词：肿瘤 虎杖 水杨梅根 藤梨根 痰毒 

分 类 号：R273[医药卫生—中西医结合]