血脂异常患者富含甘油三酯脂蛋白残粒与中医证候类型的相关性  

Study between remnant-like particle cholesterol and TCM syndromes in dyslipidemia patient

作　　者：李璐[1] 杨惠民[1] 郭杨志[2] 钱丽超 史成 罗江[3] 禹相焕 LI Lu;YANG Hui-min;GUO Yang-zhi;QIAN Li-chao;SHI Cheng;LUO Jiang;YU Xiang-huan(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China;Aerospace Center Hospital,Beijing 100143,China)

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]首都医科大学北京世纪坛医院,北京100038 [3]航天中心医院,北京100143

出　　处：《中华中医药杂志》2018年第11期4906-4908,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81503503)~~

摘　　要：目的:探讨血脂异常患者不同中医证候类型与血清RLP-C之间的差异。方法:调查155例血脂异常患者中医证候类型,并检测血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、富含甘油三酯脂蛋白残粒(RLP-C)水平,并与15名健康者对照,分析中医证候类型与检测指标相关性。结果:155例血脂异常患者中,痰浊阻遏证40例、气滞血瘀证39例、脾肾阳虚证36例、肝肾阴虚证21例、阴虚阳亢证19例。各证候类型血脂异常患者血清RLP-C水平均较正常对照组显著上升(P<0.05)。痰浊阻遏证RLP-C水平较气滞血瘀组、脾肾阳虚证、肝肾阴虚证、阴虚阳亢证显著升高(P<0.05)。结论:痰浊阻遏证、气滞血瘀证、脾肾阳虚证是血脂异常患者主要证候类型。血清RLP-C、TC、TG水平与痰浊阻遏证关系密切。Objective： To discuss the differences between the types of TCM syndromes and serum remnant-like particle cholesterol（RLP-C） of the patients with dyslipidemia. Methods： The types of TCM syndromes of 155 cases of patients with dyslipidemia were investigated. The serum total cholesterol（TC）, triglyceride（TG）, high density lipoprotein cholesterol（HDL-C）, low density lipoprotein cholesterol（LDL-C） and triglyceride-rich lipoproteins residue（RLP-C） were determined, compared with the healthy people. And the correlation between TCM syndrome types and the detected indexes were analyzed. Results： Among the 155 cases of patients with dyslipidemia, there were 40 cases of sputum stasis syndrome, 39 cases of qi stagnation and blood stasis syndrome, 36 cases of spleen-kidney yang deficiency syndrome, 21 cases of live-kidney yin deficiency syndrome and 19 cases of yin deficiency and yang hyperactivity syndrome. Serum RLP-C levels of the patients with abnormal blood lipids of all syndrome types were significantly higher than that of the normal control group（P0.05）. The RLP-C level of the group of sputum stasis syndrome was the highest, much higher than that of the qi stagnation and blood stasis group, spleen-kidney yang deficiency syndrome group, liver-kidney yin deficiency syndrome group and yin deficiency and yang hyperactivity syndrome group, and the difference was statistically significant（P0.05）. Conclusion： Sputum stasis syndrome, qi stagnation and blood stasis syndrome and spleen-kidney yang deficiency syndrome are the main types of syndrome of patients with dyslipidemia. The levels of serum RLP-C, TC and TG are closely related to sputum stasis syndrome.

关 键 词：血脂异常 富含甘油三酯脂蛋白残粒 中医证型 

分 类 号：R259[医药卫生—中西医结合]