接受IVF-ET多囊卵巢综合征患者中医证候特征及与妊娠结局关系  

Preliminary study on the TCM syndrome characteristics and the relationship with pregnancy outcome of PCOS patients with IVF-ET

作　　者：辛喜艳[1] 郭佳[1] 李东[1] XIN Xi-yan;GUO Jia;LI Dong(Department of Traditional Chinese Medicine,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院中医科,北京100191

出　　处：《中华中医药杂志》2018年第11期4909-4912,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：北京市科技计划课题(No.Z141107002514022);北京大学第三医院种子基金(No.Y82527-01)~~

摘　　要：目的:研究接受体外受精与胚胎移植(IVF-ET)的多囊卵巢综合征(PCOS)患者中医证候特征及与妊娠结局的关系。方法:以拟行IVF-ET并诊断为PCOS的195例不孕症患者为研究对象,进行中医证候、妊娠结局相关因素的观察,研究中医证候分布特征及不同妊娠结局与中医证候的关系。结果:出现频率较高的证候类型为肾气虚证(66.15%)、肾阳虚证(64.10%)、肝郁气滞证(62.56%)和痰湿证(61.03%);与妊娠成功组比较,妊娠失败组肝郁气滞证、肾阳虚证所占比重较大(P=0.046,P=0.032);发生OHSS的患者以肾阳虚证(79.41%)、痰湿证(75.00%)和肾气虚证(73.53%)为主要证候特征。结论:接受IVF-ET的PCOS患者中肾阳虚证和肝郁气滞证与妊娠结局关系密切,研究结果为PCOS患者IVF-ET前合理、有效的进行中医药辅助治疗,提高临床妊娠率提供一定的临床支持。Objective： To study the TCM syndrome characteristics and its relationship with pregnancy outcome of PCOS patients with IVF-ET. Methods： Infertile patients scheduled for IVF-ET and diagnosed with PCOS presented were taken as the research object, to observe the TCM syndromes and pregnancy outcome factors of the patients, study the distribution characteristics of TCM syndromes and relationship between different pregnancy outcomes and TCM syndromes. Results： The higher frequency syndrome types are the kidney qi deficiency syndrome（66.15%）, kidney yang deficiency syndrome（64.10%）, syndrome of liver depression and qi stagnation（62.56%） and phlegm dampness syndrome（61.03%）. Compared with the successful embryo transfer group, the main types of syndrome in failed group are syndrome of liver depression and qi stagnation and kidney yang deficiency syndrome, and the difference was statistically significant（P=0.046, P=0.032）. The kidney yang deficiency syndrome（79.41%）, phlegm dampness syndrome（75.00%） and kidney qi deficiency syndrome（73.53%） were the main syndromes in patients with OHSS. Conclusion： Kidney yang deficiency and syndrome of liver depression and qi stagnation are closely related to pregnancy outcome, and the results provide certain clinical support for the reasonable and effective adjuvant therapy of Chinese medicine for PCOS patients before IVF-ET.

关 键 词：多囊卵巢综合征 体外受精与胚胎移植 中医证候特征 妊娠结局 

分 类 号：R271.9[医药卫生—中西医结合]