丹参酮Ⅱ_A对缺血性心脏病中细胞凋亡与自噬的调控机制研究进展  

Research progress on regulation mechanism of tanshinone Ⅱ_A on cell apoptosis and autophagy in ischemic heart diseases

作　　者：冯帅 沙爽 常庆 陈颖敏[1] FENG Shuai;SHA Shuang;CHANG Qing;CHEN Ying-min(Department of Cardiovascular Medicine,Jiading District Central Hospital Affiliated Shanghai University of Medicine ＆ Health Sciences,Shanghai 201800,China;Shanghai Key Laboratory for Molecular Imaging,Shanghai University of Medicine ＆ Health Sciences,Shanghai 201318,China;Clinical Research Center,Jiading District Central Hospital Affiliated Shanghai University of Medicine ＆ Health Sciences,Shanghai 201800,China)

机构地区：[1]上海健康医学院附属嘉定区中心医院心血管内科,上海201800 [2]上海健康医学院分子影像学重点实验室,上海201318 [3]上海健康医学院附属嘉定区中心医院临床科研中心,上海201800

出　　处：《中草药》2018年第19期4670-4677,共8页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81670968);国家自然科学基金青年科学基金项目(81702284)

摘　　要：缺血性心脏病是全球发病率和致死率最高的疾病,严重地威胁着人类健康。丹参酮Ⅱ_A是从丹参的根部提取的主要亲脂性成分,研究表明,丹参酮Ⅱ_A具有多种抗心血管疾病的作用,其作用机制与调节心肌细胞的凋亡和自噬有关。论述了缺血性心脏病中细胞凋亡和自噬相关的信号通路及其相互关系,总结了近年来丹参酮Ⅱ_A通过调控细胞凋亡和自噬治疗缺血性心脏病的研究进展,探讨了其通过调控细胞凋亡和自噬从而产生心血管保护作用的机制,为深入研究缺血性心脏病以及药物的开发利用提供依据。Ischemic heart disease is a leading cause of morbidity and mortality throughout the world which is a serious threat to human health. Tanshinone Ⅱ_A is a major lipophilic component extracted from the roots of Salvia miltiorrhiza. Studies have shown that tanshinone Ⅱ_A has a variety of anti-cardiovascular diseases, and its mechanism is related to the regulation of myocardial cell apoptosis and autophagy. This article discusses the signaling pathways and their correlations related to apoptosis and autophagy in ischemic heart disease. The recent advances about the regulation of apoptosis and autophagy in the treatment to ischemia heart disease by tanshinong Ⅱ_A were summarized. The mechanism of regulating apoptosis and autophagy to produce cardiovascular protection was discussed. This paper will provide a basis for in-depth study of ischemic heart disease and the development and utilization of drugs.

关 键 词：缺血性心脏病 细胞凋亡 自噬 丹参酮ⅡA 调控机制 

分 类 号：R285[医药卫生—中药学]